About: The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells

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About: The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells
Creator	Tan, Yee-Joo Hong, Wanjin Shen, Shuo Keng, Choong-Tat Choi, Yook-Wah Lim, Gee Chan, Daphne Welkers, R
topic	covid:46dc5b817f4002a4502dd3606532b0afcc49f8fd#this
Source	Elsevier; Medline; PMC
abstract	Abstract The severe acute respiratory syndrome coronavirus (SARS-CoV), isolated from humans infected during the peak of epidemic, encodes two accessory proteins termed as 8a and 8b. Interestingly, the SARS-CoV isolated from animals contains an extra 29-nucleotide in this region such that these proteins are fused to become a single protein, 8ab. Here, we compared the cellular properties of the 8a, 8b and 8ab proteins by examining their cellular localizations and their abilities to interact with other SARS-CoV proteins. These results may suggest that the conformations of 8a and 8b are different from 8ab although nearly all the amino acids in 8a and 8b are found in 8ab. In addition, the expression of the structural protein, envelope (E), was down-regulated by 8b but not 8a or 8ab. Consequently, E was not detectable in SARS-CoV-infected cells that were expressing high levels of 8b. These findings suggest that 8b may modulate viral replication and/or pathogenesis.
has issue date	2006-10-10(xsd:dateTime)
bibo:doi	10.1016/j.virol.2006.06.026
bibo:pmid	16876844
has license	els-covid
sha1sum (hex)	46dc5b817f4002a4502dd3606532b0afcc49f8fd
schema:url	https://doi.org/10.1016/j.virol.2006.06.026
resource representing a document's title	The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells
has PubMed Central identifier	PMC7111915
has PubMed identifier	16876844
schema:publication	Virology
resource representing a document's body	covid:46dc5b817f4002a4502dd3606532b0afcc49f8fd#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/46dc5b817f4002a4502dd3606532b0afcc49f8fd
is schema:about of	named entity 'SARS-CoV' named entity 'encodes' named entity 'infected' named entity 'human' named entity 'EXTRA' named entity 'DOWN-REGULATED' named entity 'SINGLE' named entity 'EXAMINING' named entity 'EXPRESSION' named entity 'HERE' named entity 'STRUCTURAL PROTEIN' named entity 'INFECTED' named entity 'NEARLY' named entity 'FOUND' named entity 'BUT' named entity 'MODULATE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'LEVELS' named entity 'ACCESSORY' named entity 'ADDITION' named entity 'FUSED TO' named entity 'VIRAL REPLICATION' named entity 'ABILITIES' named entity 'TO INTERACT WITH' named entity 'DOWN-REGULATES' named entity 'HUMAN' named entity 'AMINO ACIDS' named entity 'CELLS' named entity 'ISOLATED' named entity 'LOCALIZATIONS' named entity 'COMPARED' named entity 'CELLS' named entity 'SUGGEST' named entity 'ENVELOPE' named entity 'REGION' named entity 'HUMANS' named entity 'CELLULAR' named entity 'SARS-COV' named entity 'ENVELOPE PROTEIN' named entity 'EXPRESSION' named entity 'INFECTED' named entity 'PROTEIN ' named entity 'ITS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'ANIMAL' named entity 'HIGH' named entity 'EPIDEMIC' named entity 'PROPERTIES' named entity 'THE PEAK' named entity 'CONTAINS' named entity 'THEIR' named entity 'DIFFERENT' named entity 'ANIMALS' named entity 'NUCLEOTIDE' named entity 'SARS-COV' named entity 'PROTEINS' named entity 'DETECTABLE' named entity 'PATHOGENESIS' named entity 'THESE' named entity 'PROTEIN' named entity 'FINDINGS' named entity 'DISTINCT FROM' named entity 'RESULTS' covid:arg/46dc5b817f4002a4502dd3606532b0afcc49f8fd named entity 'proteins' named entity 'abilities' named entity 'amino acids' named entity 'levels' named entity 'pathogenesis' named entity 'proteins' named entity 'animal' named entity 'SARS-CoV'

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