About: Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016

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About: Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
Creator	Boutolleau, D Houhou, N Bleibtreu, A Mourvillier, B Caumes, E Delemazure, J Guillot, H Jaspard, M Jaureguiberry, S Lescure, F Lucet, J Rioux, C Robert, J Vallois, D Yazdanapanah, Y
Source	Medline; PMC
abstract	BACKGROUND: Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV. METHODS: We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016. RESULTS: Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one Plasmodium falciparum malaria. Microbiological analysis identified Rhinovirus (27.9%), Influenza virus (26.8%), Legionella pneumophila (7.5%), Streptococcus pneumoniae (7.5%), and non-MERS-coronavirus (6.4%). Antibiotics were initiated in 81 (87%) cases, with two antibiotics in 63 patients (67.7%). The median duration of hospitalization and isolation was 3 days (1–33) and 24 h (8–92), respectively. Time of isolation decreased over time (P < 0.01). Two patients (2%) died. CONCLUSION: The management of patients with possible MERS-CoV infection requires medical facilities with trained personnel, and rapid access to virological results. Empirical treatment with neuraminidase inhibitors and an association of antibiotics effective against S. pneumoniae and L. pneumophila are the cornerstones of the management of patients hospitalized for suspected MERS-CoV infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12879-018-3223-5) contains supplementary material, which is available to authorized users.
has issue date	2018-07-16(xsd:dateTime)
bibo:doi	10.1186/s12879-018-3223-5
bibo:pmid	30012113
has license	cc-by
sha1sum (hex)	46da38c413e1fc657c3a7ea36435132d38a5e1b4
schema:url	https://doi.org/10.1186/s12879-018-3223-5
resource representing a document's title	Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016
has PubMed Central identifier	PMC6048819
has PubMed identifier	30012113
schema:publication	BMC Infect Dis
resource representing a document's body	covid:46da38c413e1fc657c3a7ea36435132d38a5e1b4#body_text
is schema:about of	named entity 'SUSPECTED' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'PARIS' covid:arg/46da38c413e1fc657c3a7ea36435132d38a5e1b4 named entity 'SUSPICION' named entity 'PATIENTS' named entity 'CORONAVIRUS INFECTION' named entity 'MEDICAL' named entity 'ACUTE' named entity 'SUSPECTED' named entity 'CHARACTERISTICS' named entity 'VIRAL' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'RESPIRATORY' named entity 'CLINICAL MANAGEMENT' named entity 'YEARS' named entity 'RT-PCR' named entity 'METHODS' named entity 'FINDINGS' named entity 'LEAD' named entity 'NEGATIVE' named entity 'AREA' named entity 'HOSPITALIZED' named entity 'REFERRAL' named entity 'ISOLATION' named entity 'RESULTS' named entity 'DECEMBER' named entity 'HOSPITALIZED' named entity 'MALE' named entity 'TRANSMISSION' named entity 'INFLUENZA VIRUS' named entity 'PATIENTS' named entity '2849' named entity 'RESPIRATORY' named entity 'CONFUSION' named entity 'DOCUMENTED' named entity 'IDENTIFIED' named entity 'WARDS' named entity 'BACKGROUND' named entity 'AGE' named entity 'RHINOVIRUS' named entity 'JANUARY' named entity 'PLASMODIUM FALCIPARUM MALARIA' named entity 'CAUSES' named entity 'TO AVOID' named entity 'SYNDROME' named entity 'SAUDI ARABIA' named entity 'SYNDROME' named entity 'AREA' named entity 'MEDIAN' named entity 'RETURNED' named entity 'INAPPROPRIATE' named entity 'OTHER THAN' named entity 'PARIS' named entity 'INFECTION' named entity 'CHEST X-RAY' named entity 'INFECTIOUS DISEASE' named entity 'BACTERIAL' named entity 'OUTCOME' named entity 'MANAGEMENT' named entity 'MICROBIOLOGICAL ANALYSIS' named entity 'DUE TO' named entity 'ABNORMAL' named entity 'ADULT' named entity 'Saudi Arabia' named entity 'MERS-CoV' named entity 'MERS-CoV'

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