About: Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods
Creator	Meece, Jennifer Tallo, Veronica Azziz-Baumgartner, Eduardo Levine, Min Lucero, Marilla Balmaseda, Angel Gordon, Aubree Biggs, Holly Bino, Silvia Arbaji, Ali Thompson, Mark Gerber, Susan Simões, Eric Thornburg, Natalie Al-Sanouri, Tareq Bakalli, Ilirjana De Jesus, Joanne Dhimolea, Majlinda Gresh, Lionel Hunt, Danielle Khader, Ilham Kulb, Carolyn Marar, Basima Sanchez, Felix Shifflett, Pat Simaku, Artan
topic	covid:46424059f0877fd8b689a71032608d2975fafd3d#this
Source	Medline; PMC
abstract	BACKGROUND: This multi-country prospective study of infants aged <1 year aims to assess the frequency of influenza virus and respiratory syncytial virus (RSV) infections associated with hospitalizations, to describe clinical features and antibody response to infection, and to examine predictors of very severe disease requiring intensive care. METHODS/DESIGN: We are enrolling a hospital-based cohort and a sample of non-ill infants in four countries (Albania, Jordan, Nicaragua, and the Philippines) using a common protocol. We are currently starting year 2 of a 2- to 3-year study and will enroll approximately 3,000 infants hospitalized for any acute illness (respiratory or non-respiratory) during periods of local influenza and/or RSV circulation. After informed consent and within 24 h of admission, we collect blood and respiratory specimens and conduct an interview to assess socio-demographic characteristics, medical history, and symptoms of acute illness (onset ≤10 days). Vital signs, interventions, and medications are documented daily through medical record abstraction. A follow-up health assessment and collection of convalescent blood occurs 3-5 weeks after enrollment. Influenza and RSV infection is confirmed by singleplex real time reverse transcriptase polymerase chain reaction (rRT-PCR) assays. Serologic conversion will be assessed comparing acute and convalescent sera using hemagglutination inhibition assay for influenza antibodies and enzyme-linked immunosorbent assay (ELISA) for RSV. Concurrent with hospital-based enrollment, respiratory specimens are also being collected (and tested by rRT-PCR) from approximately 1,400 non-ill infants aged <1 year during routine medical or preventive care. DISCUSSION: The Influenza and RSV in Infants Study (IRIS) promises to expand our knowledge of the frequency, clinical features, and antibody profiles of serious influenza and RSV disease among infants aged <1 year, quantify the proportion of infections that may be missed by traditional surveillance, and inform decisions about the potential value of existing and new vaccines and other prevention and treatment strategies.
has issue date	2017-03-22(xsd:dateTime)
bibo:doi	10.1186/s12879-017-2299-7
bibo:pmid	28330443
has license	cc-by
sha1sum (hex)	46424059f0877fd8b689a71032608d2975fafd3d
schema:url	https://doi.org/10.1186/s12879-017-2299-7
resource representing a document's title	Influenza and respiratory syncytial virus in infants study (IRIS) of hospitalized and non-ill infants aged <1 year in four countries: study design and methods
has PubMed Central identifier	PMC5361805
has PubMed identifier	28330443
schema:publication	BMC Infect Dis
resource representing a document's body	covid:46424059f0877fd8b689a71032608d2975fafd3d#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/46424059f0877fd8b689a71032608d2975fafd3d
is schema:about of	named entity 'influenza' named entity 'influenza' named entity 'traditional' named entity 'confirmed' named entity 'Background' named entity 'After' named entity 'infants' named entity 'real time' named entity 'abstraction' named entity 'Study' named entity 'RSV infection' named entity 'medical' named entity 'RSV' named entity 'Discussion' named entity 'circulation' named entity 'infections' named entity 'Methods' named entity 'influenza' named entity 'missed' named entity 'medications' named entity 'polymerase' named entity 'Design' named entity 'health assessment' named entity 'infants' named entity 'quantify' named entity 'periods' named entity 'infection' named entity 'reverse transcriptase polymerase chain reaction' named entity 'rRT-PCR' named entity 'RSV' named entity 'influenza virus' named entity 'vaccines' named entity 'RSV' named entity 'Influenza' named entity 'RSV' named entity 'follow-up' named entity 'acute illness' named entity 'medical history' named entity 'medical record' named entity 'enzyme-linked immunosorbent assay' named entity 'assay' named entity 'low-income countries' named entity 'real-time PCR' named entity 'influenza' named entity 'Electronic Data Capture' named entity 'ambulatory care' named entity 'epidemic' named entity 'respiratory illnesses' named entity 'viral shedding' named entity 'pneumonia' named entity 'RSV' named entity 'RSV' named entity 'etiologic agent' named entity 'virus'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software