About: The influence of collagen film nanostructure on pulmonary stem cells and collagen

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About: The influence of collagen film nanostructure on pulmonary stem cells and collagen–stromal cell interactions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The influence of collagen film nanostructure on pulmonary stem cells and collagen–stromal cell interactions
Creator	Yu, John Chang, Ying-Chih Chien, Yi-Lun Cho, Huan-Chien Huang, Chun-Jen Ling, Tai-Yen
Source	Elsevier; Medline; PMC
abstract	Abstract We have recently identified a rare subpopulation of lung colony cells with the characteristics of pulmonary stem cells, and discovered that stem cell colonies grew preferentially on type I collagen films in a serum-free medium. In order to further optimize culture conditions and determine stem cell growth in relation to microenvironments (including the stroma, medium and nanostructures of type I collagen films), both primary and pre-sorted stem cells were cultured on the type I collagen films with controllable degree of polymerization and film thickness, as confirmed by an atomic force microscope and surface profiler. We found that in a primary culture, the spreading of stromal cells is greatly restrained and both the size and number of colonies are significantly reduced on highly polymerized collagen films. In contrast, in a pre-sorted stem cell culture without stromal cells, the intrinsic stem cell properties and cell number are independent of the degree of collagen polymerization. Our results indicate that the nanostructures of type I collagen films primarily affect stem colony formation through the collagen–stroma interactions. In those cases, collagen film thickness shows no effect on colony formation.
has issue date	2010-11-30(xsd:dateTime)
bibo:doi	10.1016/j.biomaterials.2010.07.038
bibo:pmid	20673998
has license	els-covid
sha1sum (hex)	4615051fd7d1bae4ffa5ec9b8227e6bd84d6cd3f
schema:url	https://doi.org/10.1016/j.biomaterials.2010.07.038
resource representing a document's title	The influence of collagen film nanostructure on pulmonary stem cells and collagen–stromal cell interactions
has PubMed Central identifier	PMC7112499
has PubMed identifier	20673998
schema:publication	Biomaterials
resource representing a document's body	covid:4615051fd7d1bae4ffa5ec9b8227e6bd84d6cd3f#body_text
is schema:about of	named entity 'COLLAGEN' named entity 'surface' named entity 'culture' named entity 'cells' named entity 'collagen' named entity 'PROPERTIES' named entity 'NO EFFECT' named entity 'COLLAGEN' named entity 'SUBPOPULATION' named entity 'SIZE' named entity 'CONDITIONS' named entity 'CONFIRMED BY' named entity 'OUR' named entity 'PRE' named entity 'CELLS' named entity 'PRIMARY' covid:arg/4615051fd7d1bae4ffa5ec9b8227e6bd84d6cd3f named entity 'CELL' named entity 'INTERACTIONS' named entity 'PRIMARY CULTURE' named entity 'CELL GROWTH' named entity 'NUMBER OF' named entity 'INTRINSIC' named entity 'SERUM-FREE MEDIUM' named entity 'PULMONARY' named entity 'NANOSTRUCTURE' named entity 'STEM CELLS' named entity 'FILM' named entity 'ORDER' named entity 'FILM' named entity 'PULMONARY' named entity 'STEM CELLS' named entity 'GREATLY' named entity 'SORTED' named entity 'LUNG' named entity 'CHARACTERISTICS' named entity 'SURFACE PROFILER' named entity 'DETERMINE' named entity 'STEM' named entity 'RARE' named entity 'INFLUENCE' named entity 'CONTRAST' named entity 'CELL' named entity 'POLYMERIZATION' named entity 'TYPE I COLLAGEN' named entity 'CASES' named entity 'CULTURE' named entity 'COLONIES' named entity 'FOUND' named entity 'STEM CELL CULTURE' named entity 'STROMA' named entity 'HAVE' named entity 'IDENTIFIED' named entity 'STROMAL CELLS' named entity 'REDUCED' named entity 'RELATION' named entity 'AFFECT' named entity 'OPTIMIZE' named entity 'INDEPENDENT OF' named entity 'THICKNESS' named entity 'STEM CELL' named entity 'DEGREE' named entity 'MEDIUM' named entity 'SPREADING' named entity 'NUMBER' named entity 'COLONY FORMATION' named entity 'COLONY' named entity 'INTERACTIONS' named entity 'NANOSTRUCTURES' named entity 'HIGHLY' named entity 'ATOMIC FORCE MICROSCOPE' named entity 'RECENTLY' named entity 'RESULTS' named entity 'FILMS' named entity 'Our' named entity 'colony'

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