About: The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study

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About: The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study
Creator	Foulongne, Vincent Molinari, Nicolas Klouche, Kada Fesler, Pierre Le Moing, Vincent Makinson, Alain Morquin, David Renard, Eric Bertchansky, Ivan Cristol, Jean-Paul Guilpain, Philippe Jung, Boris Konate, Amadou Lamure, Sylvain Larcher, Romaric Nagot, Nicolas Raingeard, Isabelle Roubille, Camille Taourel, Patrice Villard, Orianne Maria, Jacques Thibault, Alexandre
Source	Medline; PMC
abstract	Background. The new coronavirus SARS-CoV-2, responsible for the Covid-19 pandemic, uses the angiotensin converting enzyme type 2 (ACE2), a physiological inhibitor of the renin angiotensin aldosterone system (RAAS), as a cellular receptor to infect cells. Since the RAAS can induce and modulate pro-inflammatory responses, it could play a key role in the pathophysiology of Covid-19. Thus, we aimed to determine the levels of plasma renin and aldosterone as indicators of RAAS activation in a series of consecutively admitted patients for Covid-19 in our clinic. Methods. Plasma renin and aldosterone levels were measured, among the miscellaneous investigations needed for Covid-19 management, early after admission in our clinic. Disease severity was assessed using a seven-category ordinal scale. Primary outcome of interest was the severity of patients’ clinical courses. Results. Forty-four patients were included. At inclusion, 12 patients had mild clinical status, 25 moderate clinical status and 7 severe clinical status. In univariate analyses, aldosterone and C-reactive protein (CRP) levels at inclusion were significantly higher in patients with severe clinical course as compared to those with mild or moderate course (p < 0.01 and p = 0.03, respectively). In multivariate analyses, only aldosterone and CRP levels remained positively associated with severity. We also observed a positive significant correlation between aldosterone and CRP levels among patients with an aldosterone level greater than 102.5 pmol/L. Conclusions. Both plasmatic aldosterone and CRP levels at inclusion are associated with the clinical course of Covid-19. Our findings may open new perspectives in the understanding of the possible role of RAAS for Covid-19 outcome.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.3390/jcm9072315
bibo:pmid	32708205
has license	cc-by
sha1sum (hex)	45e3fd19aa172fef951c75476c9b899ed734ae20
schema:url	https://doi.org/10.3390/jcm9072315
resource representing a document's title	The Plasmatic Aldosterone and C-Reactive Protein Levels, and the Severity of Covid-19: The Dyhor-19 Study
has PubMed Central identifier	PMC7408691
has PubMed identifier	32708205
schema:publication	J Clin Med
resource representing a document's body	covid:45e3fd19aa172fef951c75476c9b899ed734ae20#body_text
is schema:about of	named entity 'levels' named entity 'Plasma' named entity 'plasma' named entity 'needed' named entity 'severe' named entity 'early' named entity 'Study' named entity 'INDICATORS' named entity 'RENIN AND ALDOSTERONE' named entity 'COVID-19' named entity 'ROLE' named entity 'USES' named entity 'DETERMINE' named entity 'WITH SEVERITY' named entity 'FORTY' named entity 'C-REACTIVE PROTEIN' named entity 'CLINICAL COURSES' named entity 'OF INTEREST' named entity 'ORDINAL SCALE' named entity 'TO INFECT' named entity 'CONCLUSIONS' named entity 'Forty-four' named entity 'Disease' named entity 'measured' named entity 'inclusion' named entity 'CRP' named entity 'aldosterone' named entity 'patients' named entity 'physiological' named entity 'multivariate analyses' named entity 'aldosterone' named entity 'Since' named entity 'mild' named entity 'Background' named entity 'RAAS' named entity 'system' named entity 'Covid-19' named entity 'levels' named entity 'Covid-19' named entity '19 management' named entity 'aldosterone' named entity 'Covid' named entity 'ACE2' named entity 'RAAS' named entity 'aldosterone' named entity 'Covid' named entity 'aldosterone' named entity 'Covid-19' named entity 'C-reactive protein' named entity 'aldosterone' named entity 'Covid' named entity 'correlation' named entity 'aldosterone' named entity 'renin' named entity 'Student t-test' named entity 'CRP' named entity 'pro-inflammatory' named entity 'ACE2' named entity 'Spearman correlation' named entity 'CRP'

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