About: Clinical progression of patients with COVID-19 in Shanghai, China

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical progression of patients with COVID-19 in Shanghai, China
Creator	Song, Zhigang Lu, Hongzhou Xu, Qingnian Liu, Li Li, Tao Li, Feng Chen, Jun Shi, Yuxin Ling, Yun Qi, Tangkai Qian, Zhiping Shen, Yinzhong Xu, Shuibao Zeng, Yigang Zhang, Yuyi Zhu, Tongyu
source	Elsevier; Medline; PMC
abstract	Summary Background Studies on the 2019 novel coronavirus disease (COVID-19) have generally been limited to the description of the epidemiology and initial clinical characteristics. We investigated the temporal progression in patients with COVID-19. Methods In this retrospective, single-center study, we included confirmed cases of COVID-19 from Jan 20 to Feb 6, 2020 in Shanghai. Final date of follow-up was February 25, 2020. Results Of the 249 patients enrolled, the median age was 51 years old, and 126 (50.6%) were male. The duration from onset of symptoms to hospitalization was 4(2–7) days in symptomatic patients. Fever was occurred in 235(94.3%) patients. A total of 215 (86.3%) patients had been discharged after 16(12–20) days hospitalization. The estimated median duration of fever in all the patients with fever was 10 days (95 confidential intervals [CIs]: 8–11 days) after onset of symptoms. Patients who were transferred to intensive care units (ICU) had significantly longer duration of fever as compared to those not in ICU (31 days v.s. 9 days after onset of symptoms, respectively, P <0.0001). Radiological aggravation of initial image was observed in 163 (65.7%) patients on day 7 after onset of symptoms. 154(94.5%) of these patients showed radiological improvement on day 14. The median duration to negative reverse-transcriptase PCR tests of upper respiratory tract samples was 11 days (95 CIs: 10–12 days). Viral clearance was more likely to be delayed in patients in ICU than those not in ICU (P <0.0001). In multivariate logistical analysis, age (Odds ratio [OR] = 1.06) and CD4 T cell count (OR = 0.55 per 100 cells/ul increase) were independently associated with ICU admission. Conclusions The majority of COVID-19 cases are mild. The clinical progression pattern suggests that early control of viral replication and application of host-directed therapy in later stage is essential to improve the prognosis of CVOID-19.
has issue date	2020-05-31(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2020.03.004
bibo:pmid	32171869
has license	els-covid
sha1sum (hex)	45e2e4d3d64986b1b7998667350099838c7e77ab
schema:url	https://doi.org/10.1016/j.jinf.2020.03.004
resource representing a document's title	Clinical progression of patients with COVID-19 in Shanghai, China
has PubMed Central identifier	PMC7102530
has PubMed identifier	32171869
schema:publication	Journal of Infection
resource representing a document's body	covid:45e2e4d3d64986b1b7998667350099838c7e77ab#body_text
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