About: Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
Creator	Liu, Jing Adcock, Ian Chow, Vincent Ong, Hsiao Tan, Kai Wang, Bianchet, Mario Bingle, Colin Chung, Kian De, Yun Lim, Hui Lim, Rachel Rotondo, John Tan, Vivian Wang, De
source	Medline; PMC
abstract	Respiratory virus infection is one of the major sources of exacerbation of chronic airway inflammatory diseases. These exacerbations are associated with high morbidity and even mortality worldwide. The current understanding on viral-induced exacerbations is that viral infection increases airway inflammation which aggravates disease symptoms. Recent advances in in vitro air-liquid interface 3D cultures, organoid cultures and the use of novel human and animal challenge models have evoked new understandings as to the mechanisms of viral exacerbations. In this review, we will focus on recent novel findings that elucidate how respiratory viral infections alter the epithelial barrier in the airways, the upper airway microbial environment, epigenetic modifications including miRNA modulation, and other changes in immune responses throughout the upper and lower airways. First, we reviewed the prevalence of different respiratory viral infections in causing exacerbations in chronic airway inflammatory diseases. Subsequently we also summarized how recent models have expanded our appreciation of the mechanisms of viral-induced exacerbations. Further we highlighted the importance of the virome within the airway microbiome environment and its impact on subsequent bacterial infection. This review consolidates the understanding of viral induced exacerbation in chronic airway inflammatory diseases and indicates pathways that may be targeted for more effective management of chronic inflammatory diseases.
has issue date	2020-02-25(xsd:dateTime)
bibo:doi	10.3389/fcell.2020.00099
bibo:pmid	32161756
has license	cc-by
sha1sum (hex)	45a566c71056ba4faab425b4f7e9edee6320e4a4
schema:url	https://doi.org/10.3389/fcell.2020.00099
resource representing a document's title	Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium
has PubMed Central identifier	PMC7052386
has PubMed identifier	32161756
schema:publication	Front Cell Dev Biol
resource representing a document's body	covid:45a566c71056ba4faab425b4f7e9edee6320e4a4#body_text
is schema:about of	named entity 'AIRWAY' named entity 'inflammatory diseases' named entity 'upper airway' named entity 'viral infection' named entity 'impact' named entity 'AIRWAY EPITHELIUM' named entity 'AIR-LIQUID' named entity 'VIRAL INFECTION' named entity 'BARRIER' named entity 'IMMUNE RESPONSES' named entity 'CHALLENGE' named entity 'THESE' named entity 'UPPER' named entity 'OUR' named entity 'UPPER AIRWAY' named entity 'MANAGEMENT' named entity 'USE OF' named entity 'CHANGES' named entity 'HUMAN' named entity 'ASSOCIATED WITH' named entity 'ENVIRONMENT' named entity 'EPITHELIAL' named entity 'ANIMAL' named entity 'MIRNA' named entity 'SUBSEQUENT' named entity 'MICROBIAL' named entity 'NEW' named entity 'RECENT' named entity 'VIRAL INFECTIONS' named entity 'HOW' named entity 'CHRONIC' named entity 'MODULATION' named entity 'PREVALENCE' named entity 'IMPACT' named entity 'ALTER' named entity 'INDUCED' named entity 'MECHANISMS' named entity 'VIRAL-' named entity 'MORBIDITY' named entity 'APPRECIATION' named entity 'SYMPTOMS' named entity 'MODELS' named entity 'SOURCES' named entity 'ORGANOID' named entity 'CAUSING' named entity 'ITS' named entity 'EPIGENETIC' named entity 'REVIEW' named entity 'CHRONIC' named entity 'MAY BE' named entity 'REVIEW' named entity 'HIGH' named entity 'INFLAMMATORY DISEASES' named entity 'TARGETED' named entity 'ONE OF' named entity 'MAJOR' named entity 'WORLDWIDE' named entity 'UNDERSTANDING' named entity 'IN VITRO' named entity 'FINDINGS' named entity 'NOVEL' named entity 'INSIGHTS' named entity 'VIRAL INFECTIONS' named entity 'MINI' named entity 'RESPIRATORY' named entity 'INFLAMMATORY DISEASES' named entity 'UPPER AIRWAY'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software