About: Regulation of cellular innate antiviral signaling by ubiquitin modification

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of cellular innate antiviral signaling by ubiquitin modification
Creator	Zhong, Bo Lin, Dandan
Source	Medline; PMC
abstract	Host pattern-recognition receptors (PRRs) recognize pathogen-associated molecular patterns generated by invading viruses and initiate a series of signaling cascades that lead to the activation of interferon-regulatory factor 3 (IRF3) and nuclear factor-κB (NF-κB) and subsequent induction of type I interferons (IFNs). Posttranslational modification of proteins by ubiquitin plays an essential role in mediating or regulating the virus-triggered PRRs-mediated signaling. Deubiquitination is the reversible process of ubiquitination and its role in regulating PRRs-mediated signaling has recently been explored. In this review, we first summarize the ubiquitination events in PRRs-mediated signaling that is triggered by viral nucleic acid and then focus on host and viral deubiquitinating enzymes-mediated regulation of virus-triggered signaling that modulates the activation of IRF3 and NF-κB and subsequent induction of type I IFNs.
has issue date	2015-02-03(xsd:dateTime)
bibo:doi	10.1093/abbs/gmu133
bibo:pmid	25651846
has license	no-cc
sha1sum (hex)	4599e6e19a7b16de403c9fe55ac93a382eefd80d
schema:url	https://doi.org/10.1093/abbs/gmu133
resource representing a document's title	Regulation of cellular innate antiviral signaling by ubiquitin modification
has PubMed Central identifier	PMC7109689
has PubMed identifier	25651846
schema:publication	Acta Biochim Biophys Sin (Shanghai)
resource representing a document's body	covid:4599e6e19a7b16de403c9fe55ac93a382eefd80d#body_text
is schema:about of	named entity 'subsequent' named entity 'pathogen-associated molecular patterns' named entity 'activation' named entity 'signaling' named entity 'antiviral' named entity 'ASSOCIATED' named entity 'VIRUSES' named entity 'ROLE' named entity 'IRF3' named entity 'TRIGGERED' named entity 'DEUBIQUITINATION' named entity 'MOLECULAR' named entity 'PROTEINS' named entity 'SUBSEQUENT' named entity 'MEDIATED' named entity 'HOST' named entity 'TYPE I' named entity 'INITIATE' named entity 'INDUCTION' named entity 'PATTERNS' named entity 'ESSENTIAL' named entity 'REGULATION' named entity 'ANTIVIRAL' named entity 'FACTOR' named entity 'FOCUS' named entity 'POSTTRANSLATIONAL MODIFICATION' named entity 'INTERFERON' named entity 'PLAYS' named entity 'CELLULAR' named entity 'MODIFICATION' named entity 'VIRUS' named entity 'VIRAL NUCLEIC ACID' named entity 'LEAD' named entity 'REGULATION' named entity 'RECOGNITION' named entity 'PATHOGEN' named entity 'EVENTS' named entity 'TYPE I INTERFERONS' named entity 'UBIQUITINATION' named entity 'MEDIATING' named entity 'NUCLEAR' named entity 'REGULATORY' named entity 'RECEPTORS' named entity 'VIRAL' named entity 'TRIGGERED BY' named entity 'UBIQUITIN' named entity 'BAB' named entity 'SERIES' named entity 'ITS' named entity 'PRRS' named entity 'RECOGNIZE' named entity 'GENERATED' named entity 'RECENTLY' named entity 'PATTERN' named entity 'REVIEW' named entity 'SIGNALING' named entity 'REGULATING' named entity 'ACTIVATION' named entity 'SIGNALING CASCADES' named entity 'UBIQUITIN' named entity 'SIGNALING' named entity 'events' named entity 'ubiquitination' named entity 'TBK1' named entity 'TBK1' named entity 'MyD88' named entity 'cGAS' named entity 'nuclear factor-κB' named entity 'type I interferons (IFNs)' named entity 'modulates' named entity 'ubiquitin' named entity 'type I interferons' named entity 'nuclear factor-κB' named entity 'viruses' named entity 'ubiquitination' named entity 'reversible process' named entity 'pattern-recognition' named entity 'PRRs' named entity 'pathogen-associated molecular patterns' named entity 'IRF3'

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