About: Association between the Severity of Influenza A(H7N9) Virus Infections and Length of the Incubation Period

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About: Association between the Severity of Influenza A(H7N9) Virus Infections and Length of the Incubation Period Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between the Severity of Influenza A(H7N9) Virus Infections and Length of the Incubation Period
Creator	Wu, Peng Yu, Hongjie Feng, Luzhao Jiang, Hui Peng, Zhibin Zheng, Jiandong Qin, Ying Virlogeux, Victor Peiris, J Cowling, Benjamin Fang, Vicky Lau, Eric Tsang, Tim Yang,
Source	Medline; PMC
abstract	BACKGROUND: In early 2013, a novel avian-origin influenza A(H7N9) virus emerged in China, and has caused sporadic human infections. The incubation period is the delay from infection until onset of symptoms, and varies from person to person. Few previous studies have examined whether the duration of the incubation period correlates with subsequent disease severity. METHODS AND FINDINGS: We analyzed data of period of exposure on 395 human cases of laboratory-confirmed influenza A(H7N9) virus infection in China in a Bayesian framework using a Weibull distribution. We found a longer incubation period for the 173 fatal cases with a mean of 3.7 days (95% credibility interval, CrI: 3.4–4.1), compared to a mean of 3.3 days (95% CrI: 2.9–3.6) for the 222 non-fatal cases, and the difference in means was marginally significant at 0.47 days (95% CrI: -0.04, 0.99). There was a statistically significant correlation between a longer incubation period and an increased risk of death after adjustment for age, sex, geographical location and underlying medical conditions (adjusted odds ratio 1.70 per day increase in incubation period; 95% credibility interval 1.47–1.97). CONCLUSIONS: We found a significant association between a longer incubation period and a greater risk of death among human H7N9 cases. The underlying biological mechanisms leading to this association deserve further exploration.
has issue date	2016-02-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0148506
bibo:pmid	26885816
has license	cc-by
sha1sum (hex)	4589d4013cf69c396e0fdb67131022fc11119654
schema:url	https://doi.org/10.1371/journal.pone.0148506
resource representing a document's title	Association between the Severity of Influenza A(H7N9) Virus Infections and Length of the Incubation Period
has PubMed Central identifier	PMC4757028
has PubMed identifier	26885816
schema:publication	PLoS One
resource representing a document's body	covid:4589d4013cf69c396e0fdb67131022fc11119654#body_text
is schema:about of	named entity 'incubation period' named entity 'Virus' named entity 'Period' covid:arg/4589d4013cf69c396e0fdb67131022fc11119654 named entity 'disease' named entity 'person' named entity 'influenza' named entity 'H7N9' named entity 'Influenza' named entity 'Incubation Period' named entity 'Virus Infections' named entity 'infectious disease' named entity 'Bayesian framework' named entity 'incubation period' named entity 'incubation period' named entity 'incubation period' named entity 'underlying diseases' named entity '95% confidence interval' named entity 'posterior distributions' named entity 'H7N9' named entity 'SARS' named entity 'Markov Chain Monte Carlo' named entity 'coronavirus infections' named entity 'incubation period' named entity 'H7N9' named entity 'incubation period' named entity 'infection' named entity 'coronaviruses' named entity 'lungs' named entity 'infection' named entity 'viral antigens' named entity 'incubation period' named entity 'coronaviruses' named entity 'risk of death' named entity 'upper airways' named entity 'virus infection' named entity 'clinical outcome' named entity 'viruses' named entity 'viruses' named entity 'pro-inflammatory cytokines' named entity 'human disease' named entity 'censored data' named entity 'risk of death' named entity 'epidemiological data' named entity 'incubation period' named entity 'medical conditions' named entity 'prevention and control' named entity 'risk of death' named entity 'MERS' named entity 'correlation' named entity 'H7N9' named entity 'incubation period' named entity 'H7N9' named entity 'acute respiratory distress syndrome' named entity 'risk of death' named entity 'incubation period' named entity 'H5N1' named entity 'statistically significant' named entity 'SARS-CoV' named entity 'H7N9' named entity 'MERS' named entity 'incubation period' named entity 'China CDC' named entity 'MERS-CoV' named entity 'incubation period' named entity 'virus infections' named entity 'linearly correlated' named entity 'H7N9'

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