About: Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department

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About: Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department
Creator	Liu, Nan Ong, Hock Chee, Marcel Eng, Marcus Fu, Andrew Guo, Dagang Ho, Wah Koh, Zhi Leow, Su
Source	MedRxiv
abstract	Background: Chest pain is among the most common presenting complaints in the emergency department (ED). Swift and accurate risk stratification of chest pain patients in the ED may improve patient outcomes and reduce unnecessary costs. Traditional logistic regression with stepwise variable selection has been used to build risk prediction models for ED chest pain patients. In this study, we aimed to investigate if machine learning dimensionality reduction methods can achieve superior performance than the stepwise approach in deriving risk stratification models. Methods: A retrospective analysis was conducted on the data of patients >20 years old who presented to the ED of Singapore General Hospital with chest pain between September 2010 and July 2015. Variables used included demographics, medical history, laboratory findings, heart rate variability (HRV), and HRnV parameters calculated from five to six-minute electrocardiograms (ECGs). The primary outcome was 30-day major adverse cardiac events (MACE), which included death, acute myocardial infarction, and revascularization. Candidate variables identified using univariable analysis were then used to generate the stepwise logistic regression model and eight machine learning dimensionality reduction prediction models. A separate set of models was derived by excluding troponin. Receiver operating characteristic (ROC) and calibration analysis was used to compare model performance. Results: 795 patients were included in the analysis, of which 247 (31%) met the primary outcome of 30-day MACE. Patients with MACE were older and more likely to be male. All eight dimensionality reduction methods marginally but non-significantly outperformed stepwise variable selection; The multidimensional scaling algorithm performed the best with an area under the curve (AUC) of 0.901. All HRnV-based models generated in this study outperformed several existing clinical scores in ROC analysis. Conclusions: HRnV-based models using stepwise logistic regression performed better than existing chest pain scores for predicting MACE, with only marginal improvements using machine learning dimensionality reduction. Moreover, traditional stepwise approach benefits from model transparency and interpretability; in comparison, machine learning dimensionality reduction models are black boxes, making them difficult to explain in clinical practice.
has issue date	2020-07-06(xsd:dateTime)
bibo:doi	10.1101/2020.07.05.20146571
has license	medrxiv
sha1sum (hex)	457a01aa09b4ddc2c390c0ac7654982d021f576e
schema:url	https://doi.org/10.1101/2020.07.05.20146571
resource representing a document's title	Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department
resource representing a document's body	covid:457a01aa09b4ddc2c390c0ac7654982d021f576e#body_text
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