About: Hyperpolarization following activation of K(+) channels by excitatory postsynaptic potentials

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Hyperpolarization following activation of K(+) channels by excitatory postsynaptic potentials
Creator	Arch ; Trautwein, J Carmeliet, A Carmeliet, J Dude, ! Dude, W Gottstein, U Grinwa1d, W Hearse, P Irisawa, A Japan ; Trube, H Kokubun, J Lrisawa, A Marty, H Neher, A Noma, J Noma, S Sakmann, E Sakmann, G Segal, D Sigworth, B Taniguchi, E Taniguchi, F Trautwein, B Trautwein, W Vereecke, A Vleugels, E Vleugels, J
source	PMC
abstract	We have postulated that an excitatory postsynaptic potential (e.p.s.p.) may open voltage-sensitive K(+) (‘M’) channels(1), in an appropriate depolarizing range, and that this could alter the e.p.s.p. waveform. Consequently, the fast e.p.s.p. in neurones of sympathetic ganglia, elicited by a nicotinic action of acetylcholine (ACh)(2), could be followed by a hyperpolarization, produced by the opening of M channels during the depolarizing e.p.s.p. and their subsequent slow closure (time constant∼150 ms)(1). This introduces the concept that transmitter-induced p.s.ps may trigger voltage-sensitive conductances other than those initiating action potentials, and that in the present case this could produce a true post-e.p.s.p. hyperpolarization. (Some hyperpolarizations other than inhibitory postsynaptic potentials (i.p.s.ps) have been reported to follow e.p.s.ps(3,4).) We show here that this is so.
has issue date	1983-01-01(xsd:dateTime)
bibo:doi	10.1038/305148a0
bibo:pmid	6310410
has license	no-cc
sha1sum (hex)	4576a8b9e11a9c6fe5bdf863f316269eb2c3acc9
schema:url	https://doi.org/10.1038/305148a0
resource representing a document's title	Hyperpolarization following activation of K(+) channels by excitatory postsynaptic potentials
has PubMed Central identifier	PMC7095279
has PubMed identifier	6310410
schema:publication	Nature
resource representing a document's body	covid:4576a8b9e11a9c6fe5bdf863f316269eb2c3acc9#body_text
is schema:about of	named entity 'excitatory postsynaptic potential' named entity 'thalamus' named entity 'immune reactions' named entity 'protein' named entity 'electrode' named entity 'electrode' named entity 'atropine' named entity 'amplitude' named entity 'nicotinic' named entity 'intracellular' named entity 'CNS' named entity 'ACh' named entity 'extracellular' named entity 'spinal cord' named entity 'afterhyperpolarization' named entity 'ATP-sensitive K+ channel' named entity 'order of magnitude' named entity 'oligodendroglia cells' named entity 'tubocurarine' named entity 'probability' named entity 'purinergic receptor' named entity 'K+ channels' named entity 'voltage-dependent' named entity 'depolarizes' named entity 'voltage' named entity 'ADP' named entity '5.4' named entity 'EAE' named entity 'transmitter' named entity 'muscarine' named entity 'brain stem' named entity 'myelin' named entity 'hyperpolarizing' named entity 'ATP' named entity 'ganglia' named entity 'action potential' named entity 'action potential' named entity 'voltage' named entity 'Stroke' named entity 'voltage-sensitive' named entity 'abnormal posturing' named entity 'ataxic gait' named entity 'spinal cord' named entity 'experimental allergic encephalomyelitis' named entity 'tubocurarine' named entity 'neurones' named entity 'electrodes' named entity 'voltage-sensitive' named entity 'glucose' named entity 'B plus' named entity 'brain stem' named entity 'cardiac cells' named entity 'K+ channels' named entity 'hyperpolarization' named entity 'acetylcholine'

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