About: Cardiac function in relation to myocardial injury in hospitalised patients with COVID-19

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About: Cardiac function in relation to myocardial injury in hospitalised patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cardiac function in relation to myocardial injury in hospitalised patients with COVID-19
Creator	Van De Veerdonk, F Bosch, F De Korte, C De Mast, · Duijnhouwer, · Heart, Neth Hoefsloot, · Hoogerwerf, · Kok, · Koop, Y Netea, · Nijveldt, · Tjwa, · Van Den Heuvel, F Van Dijk, · Van Kimmenade, · Vos, ·
Source	Medline; PMC
abstract	BACKGROUND: Previous studies have reported on myocardial injury in patients with coronavirus infectious disease 19 (COVID-19) defined as elevated cardiac biomarkers. Whether elevated biomarkers truly represent myocardial dysfunction is not known. The aim of this study was to explore the incidence of ventricular dysfunction and assess its relationship with biomarker analyses. METHODS: This cross-sectional study ran from April 1 to May 12, 2020, and consisted of all consecutively admitted patients to the Radboud university medical centre nursing ward for COVID-19. Laboratory assessment included high-sensitivity Troponin T and N‑terminal pro-B-type natriuretic peptide (NT-proBNP). Echocardiographic evaluation focused on left and right ventricular systolic function and global longitudinal strain (GLS). RESULTS: In total, 51 patients were included, with a median age of 63 years (range 51–68 years) of whom 80% was male. Troponin T was elevated (>14 ng/l) in 47%, and a clinically relevant Troponin T elevation (10 × URL) was found in three patients (6%). NT-proBNP was elevated (>300 pg/ml) in 24 patients (47%), and in four (8%) the NT-proBNP concentration was >1,000 pg/ml. Left ventricular dysfunction (ejection fraction <52% and/or GLS >−18%) was observed in 27%, while right ventricular dysfunction (TAPSE <17 mm and/or RV S’ < 10 cm/s) was seen in 10%. There was no association between elevated Troponin T or NT-proBNP and left or right ventricular dysfunction. Patients with confirmed pulmonary embolism had normal right ventricular function. CONCLUSIONS: In hospitalised patients, it seems that COVID-19 predominantly affects the respiratory system, while cardiac dysfunction occurs less often. Based on a single echocardiographic evaluation, we found no relation between elevated Troponin T or NT-proBNP, and ventricular dysfunction. Echocardiography has limited value in screening for ventricular dysfunction. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12471-020-01458-2) contains supplementary material, which is available to authorized users.
has issue date	2020-07-08(xsd:dateTime)
bibo:doi	10.1007/s12471-020-01458-2
bibo:pmid	32643071
has license	cc-by
sha1sum (hex)	4575ec2b5578401c60678059c4282503e08a1652
schema:url	https://doi.org/10.1007/s12471-020-01458-2
resource representing a document's title	Cardiac function in relation to myocardial injury in hospitalised patients with COVID-19
has PubMed Central identifier	PMC7341471
has PubMed identifier	32643071
schema:publication	Neth Heart J
resource representing a document's body	covid:4575ec2b5578401c60678059c4282503e08a1652#body_text
is schema:about of	named entity 'injury' named entity 'inflammatory' named entity 'cardiac remodelling' named entity 'NT-proBNP' named entity 'cardiac dysfunction' named entity 'Polymerase chain reaction' named entity 'Troponin' named entity 'left ventricular dysfunction' named entity 'LVEF' named entity 'Germany' named entity '47%' named entity 'cardiac biomarkers' named entity 'pulmonary embolism' named entity 'mechanical ventilation' named entity 'myocardial injury' named entity 'coronary CT angiography' named entity 'ventricular dysfunction' named entity 'personal protective equipment' named entity 'LVEF' named entity 'microangiopathy' named entity 'Troponin' named entity 'sec' named entity 'NT-proBNP' named entity 'echocardiography' named entity 'COVID-19' named entity 'atrial fibrillation' named entity 'cardiology' named entity 'Left ventricular function' named entity 'NT-proBNP' named entity 'left ventricular' named entity 'myocardial infarction' named entity 'COVID-19' named entity 'NT-proBNP' named entity 'coronary artery bypass grafting' named entity 'NT-proBNP' named entity 'NT-proBNP' named entity 'left ventricular dysfunction' named entity 'COVID-19' named entity 'AGFA HealthCare' named entity 'TAPSE' named entity 'NT-proBNP' named entity 'Troponin' named entity 'tricuspid' named entity 'ICU' named entity 'Subgroup analyses' named entity 'natriuretic peptide' named entity 'Netherlands' named entity 'medical history' named entity 'NT-proBNP' named entity 'Troponin' named entity 'heart failure' named entity 'Vienna' named entity 'NT-proBNP' named entity 'prognosis' named entity 'mechanical ventilation' named entity 'triplane' named entity 'Cardiac function' named entity 'Left ventricular diastolic function' named entity 'ICU' named entity 'cross-sectional study' named entity 'echocardiographic' named entity 'Troponin' named entity 'Nijmegen' named entity 'Open Access' named entity 'Creative Commons licence'

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