About: CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis

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About: CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
Creator	Bergmann, Cornelia Disano, Krista Phares, Timothy Segal, Benjamin Stohlman, Stephen
Source	Elsevier; Medline; PMC
abstract	Elevated CXCL13 within the central nervous system (CNS) correlates with humoral responses in several neuroinflammatory diseases, yet its role is controversial. During coronavirus encephalomyelitis CXCL13 deficiency impaired CNS accumulation of memory B cells and antibody-secreting cells (ASC) but not naïve/early-activated B cells. However, despite diminished germinal center B cells and follicular helper T cells in draining lymph nodes, ASC in bone marrow and antiviral serum antibody were intact in the absence of CXCL13. The data demonstrate that CXCL13 is not essential in mounting effective peripheral humoral responses, but specifically promotes CNS accumulation of differentiated B cells.
has issue date	2016-05-01(xsd:dateTime)
bibo:doi	10.1016/j.bbi.2016.01.016
bibo:pmid	26795429
has license	green-oa
sha1sum (hex)	455434b57ba23f4d55f628cdc4beb99618f7f8da
schema:url	https://doi.org/10.1016/j.bbi.2016.01.016
resource representing a document's title	CXCL13 promotes isotype-switched B cell accumulation to the central nervous system during viral encephalomyelitis
has PubMed Central identifier	PMC4828287
has PubMed identifier	26795429
schema:publication	Brain, Behavior, and Immunity
resource representing a document's body	covid:455434b57ba23f4d55f628cdc4beb99618f7f8da#body_text
is schema:about of	named entity 'CXCL13' named entity 'germinal center' covid:arg/455434b57ba23f4d55f628cdc4beb99618f7f8da named entity 'B cells' named entity 'The' named entity 'essential' named entity 'CXCL13' named entity 'bone marrow' named entity 'humoral' named entity 'accumulation' named entity 'CXCL13' named entity 'bone marrow' named entity 'lymph nodes' named entity 'antibody' named entity 'CXCL13' named entity 'lymph nodes' named entity 'However' named entity 'CD8 T cells' named entity 'CXCL13' named entity 'IgG' named entity 'incubation' named entity 'virus' named entity 'TRIzol' named entity 'CXCL13' named entity 'CXCL13' named entity 'CXCR3' named entity 'CCR7' named entity 'spinal cord' named entity 'lymphoid tissue' named entity 'polypropylene' named entity 'time-point' named entity 'virus' named entity 'Collagenase' named entity 'isotype' named entity 'CCR7' named entity 'IgG' named entity 'infection' named entity 'infection' named entity 'Percoll' named entity 'microbial infections' named entity 'CXCL13' named entity 'centrifugation' named entity 'IgG' named entity 'CXCL13' named entity 'EAE' named entity 'CCL19' named entity 'IFN' named entity 'CSF' named entity 'astrocytes' named entity 'vaccination' named entity 'CXCR5' named entity 'Indianapolis' named entity 'chemokine' named entity 'CXCL12' named entity 'CLN' named entity 'phenotypic' named entity 'CSF' named entity 'CXCL13' named entity 'microglia' named entity 'GAPDH' named entity 'IL-21' named entity 'CD8 +' named entity 'serum' named entity 'CD45' named entity 'CD11b' named entity 'cryostat' named entity 'GAPDH' named entity 'brain ventricles' named entity 'CCL21' named entity 'CXCL13' named entity 'infection' named entity 'mAb' named entity 'Lerner Research' named entity 'Trypsin' named entity 'CXCL13' named entity 'isotype' named entity 'CCL19'

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