About: Specific labeling of synaptic schwann cells reveals unique cellular and molecular features

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Specific labeling of synaptic schwann cells reveals unique cellular and molecular features
Creator	Carney, Nancy Castro, Ryan Chappell, John Godbe, Kerilyn Settlage, Robert Stevens, Beth Taetzsch, Thomas Valdez, Gregorio Vaughan, Sydney
Source	PMC
abstract	Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development, function, maintenance, and repair. The study of PSCs has relied on an anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusive. This limited approach has precluded our ability to isolate and genetically manipulate PSCs in a cell specific manner. We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100β+ PSCs in skeletal muscle. NG2 is expressed in Schwann cells already associated with the NMJ, indicating that it is a marker of differentiated PSCs. Using a newly generated transgenic mouse in which PSCs are specifically labeled, we show that PSCs have a unique molecular signature that includes genes known to play critical roles in PSCs and synapses. These findings will serve as a springboard for revealing drivers of PSC differentiation and function.
has issue date	2020-06-25(xsd:dateTime)
bibo:doi	10.7554/elife.56935
bibo:pmid	32584256
has license	cc-by
sha1sum (hex)	44d08c531ae696d3ca07d00e4a4fc15ce79e3d32
schema:url	https://doi.org/10.7554/elife.56935
resource representing a document's title	Specific labeling of synaptic schwann cells reveals unique cellular and molecular features
has PubMed Central identifier	PMC7316509
has PubMed identifier	32584256
resource representing a document's body	covid:44d08c531ae696d3ca07d00e4a4fc15ce79e3d32#body_text
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