About: Antiviral and Anticancer Activity of Cisplatin Derivatives of Tilorone

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral and Anticancer Activity of Cisplatin Derivatives of Tilorone
Creator	Charles, A Roner, Michael Ae Salima, Dhanji Ae, Girish Barot, Carraher, E
Source	PMC
abstract	Cisplatin derivatives containing tilorone and a tilorone derivative were synthesized and characterized employing IR analysis, mass spectrometry, elemental analysis, and chain length. The polymeric cisplatin derivatives prevent growth of four transformed cell lines, L929, 143, Vero, and BS-C-1 and effectively inhibit four viruses including the DNA viruses; herpes simplex-1, vaccinia, and Varicella zoster, and the RNA virus, reovirus in the micrograms/mL range. The tilorone polymers display activity against both transformed cells and DNA and RNA viruses at biologically important concentrations.
has issue date	2008-06-24(xsd:dateTime)
bibo:doi	10.1007/s10904-008-9219-7
bibo:pmid	32214933
has license	no-cc
sha1sum (hex)	44c0b597fff0f6b206b04e181a1c3808d1b60957
schema:url	https://doi.org/10.1007/s10904-008-9219-7
resource representing a document's title	Antiviral and Anticancer Activity of Cisplatin Derivatives of Tilorone
has PubMed Central identifier	PMC7088078
has PubMed identifier	32214933
schema:publication	J Inorg Organomet Polym Mater
resource representing a document's body	covid:44c0b597fff0f6b206b04e181a1c3808d1b60957#body_text
is schema:about of	named entity 'Cisplatin' named entity 'synthesized' named entity 'effectively' named entity 'inhibit' named entity 'viruses' named entity 'prevent' named entity 'reovirus' named entity 'simplex' named entity 'micrograms' named entity 'transformed cells' named entity 'derivatives' named entity 'chain' named entity 'analysis' named entity 'activity' named entity 'RNA virus' named entity 'cisplatin' named entity 'DNA viruses' named entity 'DNA and RNA' named entity 'reovirus' named entity 'Cisplatin' named entity 'transformed cells' named entity 'Anticancer Activity' named entity 'Applied Biosystems' named entity 'polymers' named entity 'salts' named entity 'trypan blue' named entity 'fluorescent' named entity 'trans-effect' named entity 'cellular machinery' named entity 'acyclovir' named entity 'provirus' named entity 'small molecule' named entity 'polypeptide synthesis' named entity 'polymers' named entity 'RNA virus' named entity 'cell lines' named entity 'tilorone' named entity 'tilorone' named entity 'RNA viruses' named entity 'VZV' named entity 'high molecular weight' named entity 'potassium tetrachloroplatinate' named entity 'herpes' named entity 'retroviruses' named entity 'Knoxville' named entity 'smallpox' named entity 'RNA transcription' named entity 'rotavirus vaccine' named entity 'polymer' named entity 'juvenile diabetes' named entity 'osteosarcoma' named entity 'viral replication' named entity 'anticancer agents' named entity 'low molecular weight' named entity 'vaccinia' named entity 'Elemental analyses' named entity 'cisplatin' named entity 'polymers' named entity 'Cisplatin' named entity 'polymer' named entity 'cisplatin' named entity 'polymers' named entity 'KBr' named entity 'tilorone' named entity 'toxicity' named entity 'ion' named entity 'shingles' named entity 'RNA polymerase' named entity 'small molecule' named entity 'autoimmune' named entity 'phenylhydrazine' named entity 'trypsin' named entity 'cisplatin' named entity 'polymers' named entity 'high mass' named entity 'Tilorone'

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