About: Overnutrition in Infants Is Associated With High Level of Leptin, Viral Coinfection and Increased Severity of Respiratory Infections: A Cross-Sectional Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Overnutrition in Infants Is Associated With High Level of Leptin, Viral Coinfection and Increased Severity of Respiratory Infections: A Cross-Sectional Study
Creator	Arias-Bravo, Guisselle Inostroza, Jaime Reyes-Farías, Marjorie Valderrama, Gustavo Zorondo-Rodríguez, Francisco Rostenberghe, Hans Fuenzalida, Loreto Garcia-Diaz, Diego Ii, Zainab Jan, Hamid Khairulddin, Nik Mohamed, Jan Yusoff, Nik
Source	Medline; PMC
abstract	Objective: To investigate the relationship of overnutrition (obese and overweight) with severity of illness in children hospitalized with acute lower respiratory infections (ALRIs), frequency of viral coinfections and leptin levels. Methods: We studied 124 children <2 years old that were hospitalized for ALRI. Nutritional status was calculated by z-scores according to weight-for-age z-scores, length or height-for-age z-scores, and weight-for-height z-scores. Nasopharyngeal aspirates (NPAs) were obtained and viral respiratory pathogens were identified using reverse transcription polymerase chain reactions (RT-PCR). Respiratory syncytial virus (RSV) load was assessed using quantitative RT-PCR. NPA and plasma leptin level were measured. Clinical data and nutritional status were recorded, and patients were followed up until hospital discharge. Viral coinfection was defined as the presence of two or more viruses detected in the same respiratory sample. Severity of illness was determined by length of hospitalization and duration of oxygen therapy. Results: Children with overnutrition showed a greater frequency of viral coinfection than those with normal weight (71% obese vs. 37% normal weight p = 0.013; 68% overweight vs. 37% normal weight p = 0.004). A lower RSV load was found in obese (5.91 log(10) copies/mL) and overweight children (6.49 log(10) copies/mL) compared to normal weight children (8.06 log(10) copies/mL; p = 0.021 in both cases). In multivariate analysis, obese, and overweight infants <6 months old were associated with longer hospital stays (RR = 1.68; CI: 1.30–2.15 and obese: RR = 1.68; CI: 1.01–2.71, respectively) as well as a greater duration of oxygen therapy (RR = 1.80; IC: 1.41–2.29 and obese: RR = 1.91; CI: 1.15–3.15, respectively). Obese children <6 months showed higher plasma leptin level than normal weight children (7.58 vs. 5.12 ng/μl; p <0.046). Conclusions: In infants younger than 6 months, overnutrition condition was related to increased severity of infections and high plasma leptin level. Also, children with overnutrition showed a greater frequency of viral coinfection and low RSV viral load compared to normal weights children. These findings further contribute to the already existent evidence supporting the importance of overnutrition prevention in pediatric populations.
has issue date	2020-02-18(xsd:dateTime)
bibo:doi	10.3389/fped.2020.00044
bibo:pmid	32133330
has license	cc-by
sha1sum (hex)	44a5bfa3f7ab0f7df199e81440995ab24b8e1c58
schema:url	https://doi.org/10.3389/fped.2020.00044
resource representing a document's title	Overnutrition in Infants Is Associated With High Level of Leptin, Viral Coinfection and Increased Severity of Respiratory Infections: A Cross-Sectional Study
has PubMed Central identifier	PMC7041426
has PubMed identifier	32133330
schema:publication	Front Pediatr
resource representing a document's body	covid:44a5bfa3f7ab0f7df199e81440995ab24b8e1c58#body_text
is schema:about of	named entity 'RESPIRATORY INFECTIONS' named entity 'INFANTS' named entity 'CHILDREN HOSPITALIZED' named entity 'ACUTE' named entity 'LEPTIN' named entity 'TO INVESTIGATE' named entity 'SEVERITY OF ILLNESS' named entity 'LEVELS' named entity 'OVERWEIGHT' named entity 'VIRAL' named entity 'VIRAL' named entity 'ASSOCIATED WITH' named entity 'LOWER' named entity 'RESPIRATORY INFECTIONS' named entity 'RELATIONSHIP' named entity 'HIGH LEVEL' named entity 'SEVERITY' named entity 'COINFECTION' named entity 'OVERNUTRITION' named entity 'OBJECTIVE' named entity 'FREQUENCY' named entity 'OVERNUTRITION' named entity 'LEPTIN' named entity 'CROSS-SECTIONAL STUDY' named entity 'INCREASED' named entity 'WITH SEVERITY' covid:arg/44a5bfa3f7ab0f7df199e81440995ab24b8e1c58 named entity 'lower respiratory infections' named entity 'Woolston' named entity 'virus' named entity 'infection' named entity 'leptin' named entity 'viruses' named entity 'human coronavirus' named entity 'plasma' named entity 'epithelial' named entity 'RT-PCR' named entity 'air trapping' named entity 'epithelial tissue' named entity 'Pediatric' named entity 'leptin' named entity 'Polish' named entity 'leptin' named entity 'positively correlated' named entity 'young children' named entity 'lipid rafts' named entity 'severe infections' named entity 'dyspnea' named entity 'leptin' named entity 'RSV' named entity 'Düren' named entity 'immunodeficiency' named entity 'viruses' named entity 'obese children' named entity 'morbidity' named entity 'pathogens' named entity 'nutritional status' named entity 'OAS1' named entity 'Normal weight' named entity 'adipokine' named entity 'normal weight' named entity 'influenza' named entity 'obese' named entity 'breastfeeding' named entity 'viruses' named entity 'oxygen therapy' named entity 'PCR reaction' named entity 'enterovirus' named entity 'viral load'

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