About: An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: proof of concept

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About: An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: proof of concept Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: proof of concept
Creator	Christopher-Hennings, Jane Nelson, Eric Clement, Travis Dee, Scott Knudsen, David Nerem, Joel Schelkopf, Adam
Source	Medline; PMC
abstract	BACKGROUND: Since its initial detection in May 2013, porcine epidemic diarrhea virus (PEDV) has spread rapidly throughout the US swine industry. Initially, contaminated feed was proposed as a risk factor for PEDV; however, data were not available to support this theory. Here we provide proof of concept of this risk by describing a novel means for recovering PEDV-contaminated complete feed material from commercial swine sites and conducting an in vivo experiment to prove its infectivity. RESULTS: For on-farm detection of PEDV RNA in feed, paint rollers were used to collect material from at-risk feed bins from 3 clinically affected breeding herds. This material was tested by PCR and determined to be positive for PEDV-RNA (Ct = 19.50-22.20 range). To test infectivity, this material was pooled (Ct = 20.65) and a Treatment group of 3-week old PEDV-naïve piglets were allowed to consume it via natural feeding behavior. For the purpose of a Positive control, piglets were allowed to ingest feed spiked with stock PEDV (Ct = 18.23) while the negative control group received PEDV-free feed. Clinical signs of PEDV infection (vomiting and diarrhea) and viral shedding were observed in both the Positive control and Treatment group’ post-consumption with virus and microscopic lesions detected in intestinal samples No evidence of infection was observed in the Negative controls. CONCLUSIONS: These data provide proof of concept that contaminated complete feed can serve as a vehicle for PEDV infection of naïve pigs using natural feeding behavior.
has issue date	2014-08-05(xsd:dateTime)
bibo:doi	10.1186/s12917-014-0176-9
bibo:pmid	25091641
has license	cc-by
sha1sum (hex)	449a30a14d55d5eb735468fac84e2dca5bcf75e4
schema:url	https://doi.org/10.1186/s12917-014-0176-9
resource representing a document's title	An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: proof of concept
has PubMed Central identifier	PMC4363994
has PubMed identifier	25091641
schema:publication	BMC Vet Res
resource representing a document's body	covid:449a30a14d55d5eb735468fac84e2dca5bcf75e4#body_text
is schema:about of	named entity 'FEEDING BEHAVIOR' named entity 'EVALUATION' named entity 'feed' named entity 'proof' named entity 'PROOF OF CONCEPT' covid:arg/449a30a14d55d5eb735468fac84e2dca5bcf75e4 named entity 'VIRUS INFECTION' named entity 'INDUSTRY' named entity 'SITES' named entity 'RAPIDLY' named entity 'SPREAD' named entity 'PROVIDE' named entity 'DETECTION' named entity 'MEANS' named entity 'COMPLETE' named entity 'INITIAL' named entity 'DATA' named entity 'NOVEL' named entity 'PROOF OF CONCEPT' named entity 'FEED' named entity 'RISK FACTOR' named entity 'ITS' named entity 'BACKGROUND' named entity 'RISK' named entity 'RECOVERING' named entity 'IN VIVO EXPERIMENT' named entity 'PIGS' named entity 'FEED' named entity 'FOLLOWING' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'HERE' named entity 'DESCRIBING' named entity 'THEORY' named entity 'PROPOSED' named entity 'NOT AVAILABLE' named entity 'TO SUPPORT' named entity 'INFECTIVITY' named entity 'COMPLETE' named entity 'CONTAMINATED' named entity 'VEHICLE' named entity 'CONSUMPTION' named entity 'COMMERCIAL' named entity 'NATURAL' named entity 'SWINE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'MATERIAL' named entity 'CONDUCTING' named entity 'CONTAMINATED' named entity 'provide' named entity 'support' named entity 'feed' named entity 'swine' named entity 'evaluation' named entity 'feed material' named entity 'PEDV' named entity 'porcine epidemic diarrhea virus' named entity 'swine' named entity 'proof of concept' named entity 'porcine epidemic diarrhea virus' named entity 'ascites' named entity 'Porcine' named entity 'Canadian Food Inspection Agency' named entity 'intestinal infection' named entity 'infection' named entity 'piglet' named entity 'Positive control group' named entity 'inoculation' named entity 'Coronaviridae' named entity 'PEDV' named entity 'veterinary profession' named entity 'small intestinal' named entity 'piglet' named entity 'photomicrograph' named entity 'treatment group' named entity 'fed challenge'

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