About: NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins
Creator	Barton, Geoffrey Scott, Michelle Troshin, Peter
Source	PMC
abstract	BACKGROUND: Nucleolar localization sequences (NoLSs) are short targeting sequences responsible for the localization of proteins to the nucleolus. Given the large number of proteins experimentally detected in the nucleolus and the central role of this subnuclear compartment in the cell, NoLSs are likely to be important regulatory elements controlling cellular traffic. Although many proteins have been reported to contain NoLSs, the systematic characterization of this group of targeting motifs has only recently been carried out. RESULTS: Here, we describe NoD, a web server and a command line program that predicts the presence of NoLSs in proteins. Using the web server, users can submit protein sequences through the NoD input form and are provided with a graphical output of the NoLS score as a function of protein position. While the web server is most convenient for making prediction for just a few proteins, the command line version of NoD can return predictions for complete proteomes. NoD is based on our recently described human-trained artificial neural network predictor. Through stringent independent testing of the predictor using available experimentally validated NoLS-containing eukaryotic and viral proteins, the NoD sensitivity and positive predictive value were estimated to be 71% and 79% respectively. CONCLUSIONS: NoD is the first tool to provide predictions of nucleolar localization sequences in diverse eukaryotes and viruses. NoD can be run interactively online at http://www.compbio.dundee.ac.uk/nod or downloaded to use locally.
has issue date	2011-08-03(xsd:dateTime)
bibo:doi	10.1186/1471-2105-12-317
bibo:pmid	21812952
has license	cc-by
sha1sum (hex)	4409a3d523a0e35a95671bb6d947c39763bd0bb0
schema:url	https://doi.org/10.1186/1471-2105-12-317
resource representing a document's title	NoD: a Nucleolar localization sequence detector for eukaryotic and viral proteins
has PubMed Central identifier	PMC3166288
has PubMed identifier	21812952
schema:publication	BMC Bioinformatics
resource representing a document's body	covid:4409a3d523a0e35a95671bb6d947c39763bd0bb0#body_text
is schema:about of	named entity 'interactively' named entity 'cell' named entity 'While' named entity 'estimated' named entity 'sequences' named entity 'central' named entity 'SEQUENCE' named entity 'LARGE' named entity 'MOTIFS' named entity 'DETECTED' named entity 'HUMAN' named entity 'COMPARTMENT' named entity 'PROGRAM' named entity 'TARGETING' named entity 'RETURN' named entity 'ONLINE' named entity 'CONVENIENT' named entity 'FORM' named entity 'LIKELY' named entity 'GIVEN' named entity 'PROTEIN ' named entity 'INDEPENDENT' named entity 'TOOL' named entity 'USERS' named entity 'RESULTS' named entity 'TRAINED' named entity 'CONTROLLING' named entity 'INPUT' named entity 'EUKARYOTIC' named entity 'VERSION' named entity 'REPORTED' named entity 'SHORT' named entity 'SEQUENCES' named entity 'USING' named entity 'POSITIVE PREDICTIVE VALUE' named entity 'EUKARYOTES' named entity 'DIVERSE' named entity 'ELEMENTS' named entity 'AVAILABLE' named entity 'NUCLEOLUS' named entity 'JUST' named entity 'PROTEINS' named entity 'NUCLEOLAR' named entity 'PROTEOMES' named entity 'BACKGROUND' named entity 'OUR' named entity 'EUKARYOTIC' named entity 'ESTIMATED' named entity 'RESPONSIBLE' named entity 'HAVE' named entity 'HERE' named entity 'PREDICTOR' named entity 'DESCRIBED' named entity 'CONTAINING' named entity 'NOD' named entity 'PROTEIN SEQUENCES' named entity 'NUMBER OF' named entity 'TESTING' named entity 'DUNDEE' named entity 'CELLULAR' named entity 'RECENTLY' named entity 'VIRAL PROTEINS' named entity 'DETECTOR' named entity 'NOD' named entity 'USE' named entity 'NUCLEOLAR' named entity 'CHARACTERIZATION' named entity 'REGULATORY' named entity 'COMPLETE' named entity 'VIRAL PROTEINS' named entity 'SUBMIT' named entity 'LOCALIZATION' named entity 'THE CELL' named entity 'PROVIDED' named entity 'PRESENCE OF' named entity 'SCORE' named entity 'ROLE' named entity 'CARRIED' named entity 'BASED'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software