About: Protection of Shrimp against White Spot Syndrome Virus (WSSV) with β-1,3-d-glucan-encapsulated vp28-siRNA Particles

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Protection of Shrimp against White Spot Syndrome Virus (WSSV) with β-1,3-d-glucan-encapsulated vp28-siRNA Particles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protection of Shrimp against White Spot Syndrome Virus (WSSV) with β-1,3-d-glucan-encapsulated vp28-siRNA Particles
Creator	Zhu, Fei Zhang, Xiaobo
Source	Medline; PMC
abstract	White spot syndrome virus (WSSV) is a major shrimp viral pathogen responsible for large economic losses to shrimp aquaculture all over the world. The RNAi mediated by siRNA contributes a new strategy to control this viral disease. However, the efficient approach to deliver the siRNA into shrimp remains to be addressed. In this investigation, an antiviral vp28-siRNA was encapsulated in β-1,3-d-glucan, and then the β-1,3-d-glucan-encapsulated vp28-siRNA particles (GeRPs) were delivered into Marsupenaeus japonicus shrimp. The results showed that the vp28-siRNA in GeRPs could be released in hemocytes of shrimp. It was found that the GeRPs containing the vp28-siRNA inhibited the replication of WSSV in vivo, which presented a better antiviral activity than the non-encapsulated vp28-siRNA. Further evidence indicated that the mortality of WSSV-infected shrimp was significantly delayed by the GeRPs containing vp28-siRNA. Therefore, our study presented that the glucan-encapsulated siRNA might represent a novel potential therapeutic or preventive approach to control the shrimp disease.
has issue date	2011-05-18(xsd:dateTime)
bibo:doi	10.1007/s10126-011-9387-2
bibo:pmid	21590271
has license	no-cc
sha1sum (hex)	43c83bde51b9566d929c7ef8edab4520b30656ed
schema:url	https://doi.org/10.1007/s10126-011-9387-2
resource representing a document's title	Protection of Shrimp against White Spot Syndrome Virus (WSSV) with β-1,3-d-glucan-encapsulated vp28-siRNA Particles
has PubMed Central identifier	PMC7087676
has PubMed identifier	21590271
schema:publication	Mar Biotechnol (NY)
resource representing a document's body	covid:43c83bde51b9566d929c7ef8edab4520b30656ed#body_text
is schema:about of	named entity 'SIRNA' named entity 'strategy' named entity 'mediated' named entity 'particles' named entity 'siRNA' named entity 'WSSV' named entity 'PARTICLES' named entity 'VIRAL PATHOGEN' named entity 'TO DELIVER' named entity 'RELEASED' named entity 'MARSUPENAEUS JAPONICUS' named entity 'COULD BE' named entity 'IN VIVO' named entity 'D-GLUCAN' named entity 'A MAJOR' named entity 'RNAI' named entity 'BETTER' named entity 'POTENTIAL' covid:arg/43c83bde51b9566d929c7ef8edab4520b30656ed named entity 'PROTECTION' named entity 'DISEASE' named entity 'RESULTS' named entity 'FOUND' named entity 'CONTAINING' named entity 'STRATEGY' named entity 'IS A' named entity 'ENCAPSULATED' named entity 'B2-1' named entity 'WHITE SPOT SYNDROME VIRUS' named entity 'PARTICLES' named entity 'EVIDENCE' named entity 'INVESTIGATION' named entity 'SIRNA' named entity 'RESPONSIBLE' named entity 'STUDY' named entity 'PRESENTED' named entity 'APPROACH' named entity 'MORTALITY' named entity 'INHIBITED' named entity 'TO CONTROL' named entity 'ENCAPSULATED' named entity 'DELAYED' named entity 'SHRIMP AQUACULTURE' named entity 'NON-' named entity 'DELIVERED' named entity 'SHRIMP' named entity 'D-GLUCAN' named entity 'PREVENTIVE' named entity 'THERAPEUTIC' named entity 'ECONOMIC' named entity 'INFECTED' named entity 'ANTIVIRAL' named entity 'INDICATED' named entity 'NEW' named entity 'WSSV' named entity 'VIRAL DISEASE' named entity 'SHRIMP' named entity 'REPRESENT' named entity 'WORLD' named entity 'EFFICIENT' named entity 'NOVEL' named entity 'OUR' named entity 'REPLICATION' named entity 'LARGE' named entity 'B2-1' named entity 'HEMOCYTES' named entity 'MEDIATED' named entity 'GLUCAN' named entity 'ANTIVIRAL ACTIVITY' named entity 'WHITE SPOT SYNDROME VIRUS' named entity 'therapeutic' named entity 'shrimp' named entity 'presented' named entity 'siRNA' named entity 'siRNA' named entity 'replication' named entity 'shrimp' named entity 'WSSV' named entity 'siRNA' named entity 'viral pathogen'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software