About: Delirium Incidence, Duration and Severity in Critically Ill Patients with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Delirium Incidence, Duration and Severity in Critically Ill Patients with COVID-19
Creator	Rahman, Omar Machado, Roberto Roberts, Scott Khan, Babar Khan, Sikandar Boustani, Malaz Farber, Mark Gao, Sujuan Jamil, Yasser Lindroth, Heidi Marcantonio, Edward Perkins, Anthony Wang, Sophia
Source	MedRxiv
abstract	Background Delirium incidence, duration and severity in patients admitted to the intensive care unit (ICU) due to COVID-19 is not known. Methods We conducted an observational study at two large urban academic Level 1 trauma centers. Consecutive patients admitted to the ICU with a positive SARS-CoV-2 nasopharyngeal swab polymerase chain reaction test from March 1st, 2020 to April 27, 2020 were included. Individuals younger than 18 years of age, without any documented delirium assessments (CAM-ICU), or without a discharge disposition were excluded. The primary outcomes were delirium rates and delirium duration and the secondary outcome was delirium severity. Outcomes were assessed for up to the first 14 days of ICU stay. Results Of 243 consecutive patients with confirmed COVID-19 admitted to the ICU, 144 met eligibility criteria and were included in the analysis. Delirium occurred in 73.6% (106/144) and delirium or coma occurred in 76.4% (110/144). Sixty-three percent of patients were positive for delirium on the first CAM-ICU assessment. The median duration of delirium and coma was 7 days (IQR: 3-10), and the median delirium duration was 5 days (IQR: 2-7). The median CAM-ICU-7 score was 6 (IQR: 4-7) representing severe delirium. Mechanical ventilation was associated with greater odds of developing delirium (OR: 42.1, 95%CI: 13.0-137.1). Mortality was 26.4% in patients with delirium compared to 15.8% in patients without delirium. Conclusions 73.6% of patients admitted to the ICU with COVID-19 experience delirium that persists for approximately 1 week. Invasive mechanical ventilation is significantly associated with odds of delirium. Clinical attention to prevent and manage delirium and reduce delirium duration and severity is urgently needed for patients with COVID-19.
has issue date	2020-06-01(xsd:dateTime)
bibo:doi	10.1101/2020.05.31.20118679
has license	medrxiv
sha1sum (hex)	43a1fe6af20e48be3f57effd05500df05799a3ff
schema:url	https://doi.org/10.1101/2020.05.31.20118679
resource representing a document's title	Delirium Incidence, Duration and Severity in Critically Ill Patients with COVID-19
resource representing a document's body	covid:43a1fe6af20e48be3f57effd05500df05799a3ff#body_text
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