About: Unexplained diarrhoea in HIV-1 infected individuals

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Unexplained diarrhoea in HIV-1 infected individuals
Creator	Molenkamp, Richard Canuti, Marta Deijs, Martin Chung, Kevin Cotten, Matthew Rebers, Sjoerd Snijders, Fransje Jebbink, Maarten Oude Munnink, Bas De Vries, Michel Van Der Hoek, Lia Van Hemert, Formijn Sol, J
Source	Medline; PMC
abstract	BACKGROUND: Gastrointestinal symptoms, in particular diarrhoea, are common in non-treated HIV-1 infected individuals. Although various enteric pathogens have been implicated, the aetiology of diarrhoea remains unexplained in a large proportion of HIV-1 infected patients. Our aim is to identify the cause of diarrhoea for patients that remain negative in routine diagnostics. METHODS: In this study stool samples of 196 HIV-1 infected persons, including 29 persons with diarrhoea, were examined for enteropathogens and HIV-1. A search for unknown and unexpected viruses was performed using virus discovery cDNA-AFLP combined with Roche-454 sequencing (VIDISCA-454). RESULTS: HIV-1 RNA was detected in stool of 19 patients with diarrhoea (66%) compared to 75 patients (45%) without diarrhoea. In 19 of the 29 diarrhoea cases a known enteropathogen could be identified (66%). Next to these known causative agents, a range of recently identified viruses was identified via VIDISCA-454: cosavirus, Aichi virus, human gyrovirus, and non-A non-B hepatitis virus. Moreover, a novel virus was detected which was named immunodeficiency-associated stool virus (IASvirus). However, PCR based screening for these viruses showed that none of these novel viruses was associated with diarrhoea. Notably, among the 34% enteropathogen-negative cases, HIV-1 RNA shedding in stool was more frequently observed (80%) compared to enteropathogen-positive cases (47%), indicating that HIV-1 itself is the most likely candidate to be involved in diarrhoea. CONCLUSION: Unexplained diarrhoea in HIV-1 infected patients is probably not caused by recently described or previously unknown pathogens, but it is more likely that HIV-1 itself plays a role in intestinal mucosal abnormalities which leads to diarrhoea.
has issue date	2014-01-13(xsd:dateTime)
bibo:doi	10.1186/1471-2334-14-22
bibo:pmid	24410947
has license	cc-by
sha1sum (hex)	439ddbbdb17f5ab18ac2e208e7df5c09a8dc9789
schema:url	https://doi.org/10.1186/1471-2334-14-22
resource representing a document's title	Unexplained diarrhoea in HIV-1 infected individuals
has PubMed Central identifier	PMC3925291
has PubMed identifier	24410947
schema:publication	BMC Infect Dis
resource representing a document's body	covid:439ddbbdb17f5ab18ac2e208e7df5c09a8dc9789#body_text
is schema:about of	named entity 'DIARRHOEA' named entity 'patients' named entity 'combined' named entity 'pathogens' named entity 'UNEXPLAINED' named entity 'INFECTED' named entity 'PERFORMED' named entity 'SEARCH' named entity 'ROUTINE' named entity 'PARTICULAR' named entity 'VIRUSES' named entity 'TREATED' named entity 'STOOL' named entity 'STUDY' named entity 'CDNA-AFLP' named entity 'VARIOUS' named entity '454 SEQUENCING' named entity 'INDIVIDUALS' named entity 'AIM' named entity '196' named entity 'GASTROINTESTINAL SYMPTOMS' named entity 'PATIENTS' named entity 'UNEXPLAINED' named entity 'OUR' named entity 'INDIVIDUALS' named entity 'PROPORTION' named entity '454' named entity 'SAMPLES' named entity 'PERSONS' named entity 'INFECTED' named entity 'NON-' named entity 'DIARRHOEA' named entity 'ENTERIC' named entity 'NEGATIVE' named entity 'CAUSE' named entity 'USING' named entity 'COMBINED' named entity 'HIV-1' named entity 'UNEXPECTED' named entity 'METHODS' named entity 'COMMON' named entity 'PATHOGENS' named entity 'VIRUS' named entity 'HIV-1' named entity 'EXAMINED FOR' named entity 'DIAGNOSTICS' named entity 'BACKGROUND' named entity 'DISCOVERY' named entity 'AETIOLOGY' named entity 'INCLUDING' named entity 'TO IDENTIFY' named entity 'UNKNOWN' named entity 'LARGE' named entity 'HAVE' named entity 'ROCHE' named entity 'infected' named entity 'diarrhoea' named entity 'HIV-1' named entity 'infected' named entity 'large' named entity 'diarrhoea' named entity 'diarrhoea' named entity 'HIV-1' named entity '454 sequencing' named entity 'pathogens' named entity 'aetiology' named entity 'Roche' named entity 'Gastrointestinal symptoms' named entity 'diarrhoea'

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