About: Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes
Creator	Schmaling, Summer Gaglia, Marta Mccormick, Craig Rivas, Hembly
source	Medline; PMC
abstract	The ability to shut off host gene expression is a shared feature of many viral infections, and it is thought to promote viral replication by freeing host cell machinery and blocking immune responses. Despite the molecular differences between viruses, an emerging theme in the study of host shutoff is that divergent viruses use similar mechanisms to enact host shutoff. Moreover, even viruses that encode few proteins often have multiple mechanisms to affect host gene expression, and we are only starting to understand how these mechanisms are integrated. In this review we discuss the multiplicity of host shutoff mechanisms used by the orthomyxovirus influenza A virus and members of the alpha- and gamma-herpesvirus subfamilies. We highlight the surprising similarities in their mechanisms of host shutoff and discuss how the different mechanisms they use may play a coordinated role in gene regulation.
has issue date	2016-04-16(xsd:dateTime)
bibo:doi	10.3390/v8040102
bibo:pmid	27092522
has license	cc-by
sha1sum (hex)	43740caefa35d11ce1aa130cd8ca86b60442b046
schema:url	https://doi.org/10.3390/v8040102
resource representing a document's title	Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes
has PubMed Central identifier	PMC4848596
has PubMed identifier	27092522
schema:publication	Viruses
resource representing a document's body	covid:43740caefa35d11ce1aa130cd8ca86b60442b046#body_text
is schema:about of	named entity 'viral replication' named entity 'regulation' named entity 'viruses' named entity 'host' named entity 'Herpesviruses' named entity 'INFLUENZA A VIRUS' named entity 'MULTIPLICITY' named entity 'MULTIPLE' named entity 'FEATURE' named entity 'MOLECULAR' named entity 'ORTHOMYXOVIRUS' named entity 'ROLE' named entity 'MEMBERS' named entity 'INFLUENZA A VIRUS' named entity 'DIFFERENT' named entity 'USE' named entity 'HERPESVIRUS' named entity 'IMMUNE RESPONSES' named entity 'HOST CELL' named entity 'DISCUSS' named entity 'PLAY' named entity 'GENE REGULATION' named entity 'HOW' named entity 'AFFECT' named entity 'HOST' named entity 'GENE EXPRESSION' named entity 'VIRAL REPLICATION' named entity 'SIMILAR' named entity 'REVIEW' named entity 'MECHANISMS' named entity 'THESE' named entity 'HERPESVIRUSES' named entity 'HAVE' named entity 'COMMON' named entity 'VIRUSES' named entity 'SIMILAR' named entity 'VIRUSES' named entity 'COORDINATED' named entity 'SHARED' named entity 'INTEGRATED' named entity 'HOST' named entity 'ENCODE' named entity 'THEIR' named entity 'MECHANISMS' named entity 'STUDY' named entity 'MACHINERY' named entity 'BLOCKING' named entity 'THEME' named entity 'ALPHA' named entity 'GENE EXPRESSION' named entity 'STARTING' named entity 'USED BY' named entity 'IS A' named entity 'PROTEINS' named entity 'THOUGHT' named entity 'PROMOTE' named entity 'VIRAL INFECTIONS' named entity 'UNDERSTAND' named entity 'surprising' named entity 'host' named entity 'coordinated' named entity 'gene' named entity 'viruses' named entity 'gene' named entity 'expression' named entity 'Mechanisms' named entity 'gene expression' named entity 'gene expression' named entity 'Shutoff' named entity 'viruses' named entity 'highlight' named entity 'vhs' named entity 'viral replication' named entity 'reading frames' named entity 'spliceosome' named entity 'polyadenylation complex' named entity 'HSV-1 infection' named entity 'mRNAs'

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