About: Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain

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About: Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain
Creator	Ashwell, M Benito, J Freire, M Hash, J Lascelles, B Mcculloch, R O'nan, A
Source	Elsevier; Medline; PMC
abstract	Abstract Degenerative joint disease (DJD) associated-pain is a clinically relevant and common condition affecting domesticated cats and other species including humans. Identification of the neurobiological signature of pain is well developed in rodent pain models, however such information is lacking from animals or humans with naturally occurring painful conditions. In this study, identification of housekeeping genes (HKG) for neuronal tissue and expression levels of genes considered associated with chronic pain in rodent models were explored in cats with naturally occurring osteoarthritic pain. Fourteen adult cats were evaluated — seven without clinical signs of osteoarthritic pain, and seven with hind limb radiographic DJD and pain. Expression of an investigator-selected set of pain signaling genes (including ASIC3, ATF3, COX2, CX3CL1, NAV1.7, NAV1.8, NAV1.9, NGF, NK1R, TNFα, TRKA) in lumbar spinal cord dorsal horn and lumbar dorsal root ganglia tissues from clinically healthy cats and cats with DJD were studied using quantitative RT-PCR (qPCR). HKG identified as the most stable across all tissue samples were many of the ribosomal protein genes, such as RPL30 and RPS19. qPCR results showed ATF3 and CX3CL1 up-regulated in DJD-affected dorsal root ganglia compared to clinically healthy controls. In spinal cord, CX3CL1 was up-regulated and NGF was down-regulated when DJD-affected samples were compared to healthy samples. Further work is needed to understand the neurobiology of pain in naturally occurring disease and what rodent models are predictive of these changes in more heterogeneous populations such as domestic cats.
has issue date	2019-01-31(xsd:dateTime)
bibo:doi	10.1016/j.tvjl.2018.11.008
bibo:pmid	30606438
has license	els-covid
sha1sum (hex)	435bba6a9fa47ef09570e309bb958a36bac86f8a
schema:url	https://doi.org/10.1016/j.tvjl.2018.11.008
resource representing a document's title	Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain
has PubMed Central identifier	PMC7129418
has PubMed identifier	30606438
schema:publication	The Veterinary Journal
resource representing a document's body	covid:435bba6a9fa47ef09570e309bb958a36bac86f8a#body_text
is schema:about of	named entity 'HKG' named entity 'humans' named entity 'adult' named entity 'humans' named entity 'degenerative' named entity 'CHARACTERIZATION' named entity 'DEGENERATIVE JOINT DISEASE' named entity 'LACKING' named entity 'HIND LIMB' named entity 'GENES' named entity 'SET' named entity 'HEALTHY' covid:arg/435bba6a9fa47ef09570e309bb958a36bac86f8a named entity 'GENE EXPRESSION' named entity 'NAV1.8' named entity 'ADULT' named entity 'HUMANS' named entity 'HOUSEKEEPING GENES' named entity 'INFORMATION' named entity 'IS A' named entity 'STUDY' named entity 'COMMON' named entity 'ASSOCIATED WITH' named entity 'SIGNALING' named entity 'RODENT' named entity 'SEVEN' named entity 'SELECTED' named entity 'NATURALLY OCCURRING' named entity 'ASSOCIATED' named entity 'TRKA' named entity 'TNF' named entity 'LUMBAR SPINAL CORD DORSAL HORN' named entity 'ASSOCIATED' named entity 'CATS' named entity 'USING' named entity 'PAIN' named entity 'CONDITIONS' named entity 'INCLUDING' named entity 'CONDITION' named entity 'SIGNATURE' named entity 'NK1R' named entity 'ATF3' named entity 'NAV1.9' named entity 'ASIC3' named entity 'COX2' named entity 'QUANTITATIVE RT-PCR' named entity 'CX3CL1' named entity 'LUMBAR' named entity 'SPECIES' named entity 'NGF' named entity 'DORSAL ROOT GANGLIA' named entity 'LEVELS' named entity 'FOURTEEN' named entity 'TISSUE' named entity 'RELEVANT' named entity 'AFFECTING' named entity 'IDENTIFICATION' named entity 'NAV1.7' named entity 'CONSIDERED' named entity 'RADIOGRAPHIC' named entity 'DEGENERATIVE JOINT DISEASE' named entity 'MODELS' named entity 'CHRONIC PAIN' named entity 'INVESTIGATOR' named entity 'NEURONAL' named entity 'ANIMALS' named entity 'TISSUES' named entity 'PAIN' named entity 'FELINE' named entity 'NATURALLY OCCURRING' named entity 'EXPRESSION' named entity 'PAINFUL' named entity 'limb' named entity 'DJD' named entity 'species'

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