About: Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection
Creator	Cheng, Mei-Ling Ho, Hung-Yao Shih, Shin-Ru Chiu, Daniel Tsun-Yee Wu, Yi-Hsuan Tseng, Ching-Ping
Source	Medline; PMC
abstract	The host cellular environment is a key determinant of pathogen infectivity. Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)–deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of infection. These phenomena were correlated with increased oxidant production. Accordingly, ectopic expression of G6PD in G6PD-deficient cells or addition of antioxidant (such as α-lipoic acid) to G6PD-knockdown cells attenuated the increased susceptibility to HCoV 229E infection. All experimental data indicated that oxidative stress in host cells is an important factor in HCoV 229E infectivity
has issue date	2008-03-15(xsd:dateTime)
bibo:doi	10.1086/528377
bibo:pmid	18269318
has license	no-cc
sha1sum (hex)	432dd563db1d1ed6f26e4a590519afa7ee887006
schema:url	https://doi.org/10.1086/528377
resource representing a document's title	Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection
has PubMed Central identifier	PMC7199897
has PubMed identifier	18269318
schema:publication	J Infect Dis
resource representing a document's body	covid:432dd563db1d1ed6f26e4a590519afa7ee887006#body_text
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