About: The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients

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About: The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients
Creator	Hakki, Morgan Press, Richard Rattray, Rogan
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Compared to other respiratory viruses, relatively little is known about the clinical impact of coronavirus (CoV) infection after hematopoietic stem cell transplant (HSCT) or in patients with hematologic malignancies. OBJECTIVES: To characterize the role of CoV in respiratory tract infections among HSCT and hematologic malignancy patients. STUDY DESIGN: We conducted a retrospective review of all cases of CoV infection documented by polymerase chain reaction, (PCR)-based testing on nasopharyngeal and bronchoalveolar lavage fluid samples between June 2010 and 2013. Cases of CoV infection occurring in HSCT and hematologic malignancy patients were identified and the clinical characteristics of these cases were compared to other respiratory viruses. RESULTS: CoV was identified in 2.6% (n = 43) of all samples analyzed (n = 1661) and in 6.8% of all samples testing positive for a respiratory virus (n = 631). 33 of 38 (86.8%) of patients in whom CoV was identified were HSCT and hematologic malignancy patients. Among these patients, CoV was detected in 9.7% of unique infection episodes, with only rhinovirus/enterovirus (RhV/EnV) infection being more common. Group I CoV subtypes accounted for 76.3% of cases, and 57% of infections were diagnosed between December and March. CoV infection was associated with upper respiratory tract symptoms in most patients, similar to other respiratory viruses. Possible and proven lower respiratory tract disease was less common compared to other respiratory viruses except RhV/EnV. CONCLUSIONS: CoV is frequently detected in HSCT and hematologic malignancy patients in whom suspicion for a respiratory viral infection exists, but is less likely to progress to lower respiratory tract disease than most other respiratory viruses.
has issue date	2015-04-15(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2015.04.012
bibo:pmid	26071326
has license	no-cc
sha1sum (hex)	432a9661e8c0a00f31e4e276a808a0a47860bbb5
schema:url	https://doi.org/10.1016/j.jcv.2015.04.012
resource representing a document's title	The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients
has PubMed Central identifier	PMC7106547
has PubMed identifier	26071326
schema:publication	J Clin Virol
resource representing a document's body	covid:432a9661e8c0a00f31e4e276a808a0a47860bbb5#body_text
is schema:about of	named entity 'unique' named entity 'subtypes' named entity 'December' named entity 'documented' named entity 'patients' named entity 'polymerase' named entity 'viruses' named entity 'respiratory' named entity 'infection' named entity 'HEMATOPOIETIC STEM CELL' named entity 'RESULTS' named entity 'CONCLUSIONS' named entity 'HEMATOPOIETIC STEM CELL' named entity 'CORONAVIRUS' named entity 'UPPER RESPIRATORY TRACT SYMPTOMS' named entity 'LITTLE' named entity 'SAMPLES' named entity 'HEMATOLOGIC MALIGNANCIES' named entity 'STEM CELL TRANSPLANT' covid:arg/432a9661e8c0a00f31e4e276a808a0a47860bbb5 named entity 'CORONAVIRUS INFECTION' named entity 'EXCEPT' named entity 'PROVEN' named entity 'RESPIRATORY VIRAL INFECTION' named entity 'NASOPHARYNGEAL' named entity 'POLYMERASE CHAIN REACTION' named entity 'TESTING' named entity 'ANALYZED' named entity 'SUSPICION' named entity 'BASED' named entity 'DECEMBER' named entity 'REVIEW OF' named entity 'INFECTIONS' named entity 'SIMILAR' named entity 'CLINICAL' named entity 'OBJECTIVES' named entity 'DETECTED' named entity 'KNOWN' named entity '2.6' named entity 'DIAGNOSED' named entity 'ROLE' named entity 'HEMATOLOGIC MALIGNANCIES' named entity 'PATIENTS' named entity 'UNIQUE' named entity 'INFECTION' named entity 'DOCUMENTED' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'IDENTIFIED' named entity 'RETROSPECTIVE' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'ABOUT' named entity 'COMPARED' named entity 'LIKELY' named entity 'GROUP I' named entity '1661' named entity 'THESE' named entity 'PROGRESS' named entity 'HEMATOLOGIC MALIGNANCY' named entity 'CASES' named entity 'JUNE' named entity 'PATIENTS' named entity 'TRANSPLANT RECIPIENTS' named entity 'STEM CELL TRANSPLANT' named entity 'POSSIBLE' named entity 'RHINOVIRUS' named entity 'EPISODES' named entity 'BACKGROUND' named entity 'POSITIVE FOR' named entity 'LOWER RESPIRATORY TRACT DISEASE' named entity '2886' named entity 'CLINICAL CHARACTERISTICS' named entity 'BUT' named entity 'MARCH' named entity 'ASSOCIATED WITH' named entity 'TO CHARACTERIZE' named entity 'SUBTYPES' named entity 'HSCT' named entity 'IMPACT' named entity 'RESPIRATORY VIRUSES'

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