About: Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection

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About: Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection
Creator	Huang, Hong Lin, Hao Chen, Rui-Lie Chi, Ze-Pai Fan, Jing-Ru Guo, Shun-Qi Hong, Xu-Wei Lin, Xian-Wei Liu, Guo-Yuan Pan, Ze-Qun Qu, Liao-Zhun Wang, Liang-Yu Wu, Ling-Jie Wu, Su-Wu Zhang, Qi-Chuan Zhang, Yong-Hai Zhou, Yu-Hua
Source	MedRxiv
abstract	Objectives The aim of the study was to analyze the incidence of COVID-19 with early renal injury, and to explore the value of multi-index combined detection in diagnosis of early renal injury in COVID-19. Design The study was an observational, descriptive study. Setting This study was carried out in a tertiary hospital in Guangdong, China. Participants 12 patients diagnosed with COVID-19 from January 20, 2020 to February 20, 2020. Primary and secondary outcome measures The primary outcome was to evaluate the incidence of early renal injury in COVID-19. In this study, the estimated glomerular filtration rate (eGFR), endogenous creatinine clearance (Ccr) and urine microalbumin / urinary creatinine ratio (UACR) were calculated to assess the incidence of early renal injury. Secondary outcomes were the diagnostic value of urine microalbumin (UMA), 1-microglobulin (A1M), urine immunoglobulin-G (IGU), urine transferring (TRU) alone and in combination in diagnosis of COVID-19 with early renal injury. Results While all patients had no significant abnormalities in serum creatinine (Scr) and blood urea nitrogen (BUN), the abnormal rates of eGFR, Ccr, and UACR were 66.7%, 41.7%, and 41.7%, respectively. Urinary microprotein detection indicated that the area under curve (AUC) of multi-index combined to diagnose early renal injury in COVID-19 was 0.875, which was higher than UMA (0,813), A1M (0.813), IGU (0.750) and TRU (0.750) alone. Spearman analysis showed that the degree of early renal injury was significantly related to C-reactive protein (CRP) and neutrophil ratio (NER), suggesting that the more severe the infection, the more obvious the early renal injury. Hypokalemia and hyponatremia were common in patients with COVID-19, and there was a correlation with the degree of renal injury. Conclusions Early renal injury was common in patients with COVID-19. Combined detection of UMA, A1M, IGU, and TRU was helpful for the diagnosis of early renal injury in COVID-19.
has issue date	2020-03-10(xsd:dateTime)
bibo:doi	10.1101/2020.03.07.20032599
has license	medrxiv
sha1sum (hex)	42fd59678b98ad2d5416d95b54118d3dfbdd2f30
schema:url	https://doi.org/10.1101/2020.03.07.20032599
resource representing a document's title	Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection
resource representing a document's body	covid:42fd59678b98ad2d5416d95b54118d3dfbdd2f30#body_text
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