About: M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis

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About: M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis
Creator	Arival, Cardoso Cristina, Tania De, Brito Juarez, Antonio Luciane, Kanashiro-Galo Maria, Irma Mirian, Barboza Pagliari, Seixas, Duarte Simões, Quaresma Sotto, Nacagami
Source	Medline; PMC
abstract	Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. We investigated the population of M1 and M2 polarized macrophages in human cutaneous lesions. A total of 27 biopsies from human lesions were submitted to an immunohistochemistry protocol using antibodies to detect M1 and M2 macrophages (Arginase-1, CD163, iNOS, RBP-J and cMAF). We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). The results suggest a predominant phenotype of M2 macrophages, which have an immunomodulatory role and probably contributing to chronicity of Lacaziosis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11046-020-00450-z) contains supplementary material, which is available to authorized users.
has issue date	2020-05-06(xsd:dateTime)
bibo:doi	10.1007/s11046-020-00450-z
bibo:pmid	32378114
has license	no-cc
sha1sum (hex)	42a6fd4f30e6c37c8b086df0b39b24df5952dd12
schema:url	https://doi.org/10.1007/s11046-020-00450-z
resource representing a document's title	M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis
has PubMed Central identifier	PMC7201388
has PubMed identifier	32378114
schema:publication	Mycopathologia
resource representing a document's body	covid:42a6fd4f30e6c37c8b086df0b39b24df5952dd12#body_text
is schema:about of	named entity 'immune response' named entity 'population' named entity 'promotes' named entity 'cutaneous' named entity 'protocol' named entity 'predominant' named entity 'macrophages' named entity 'Cutaneous' covid:arg/42a6fd4f30e6c37c8b086df0b39b24df5952dd12 named entity 'profile' named entity 'human' named entity 'host' named entity 'lesions' named entity 'elements' named entity 'lesions' named entity 'CD163' named entity 'chronic' named entity 'microbicidal' named entity 'antibodies' named entity 'microenvironment' named entity 'total' named entity 'macrophage' named entity 'microbicidal' named entity 'iNOS' named entity 'M2 macrophages' named entity 'Lacazia loboi' named entity 'mycosis' named entity 'immune response' named entity 'Th1' named entity 'CD163' named entity 'cytokines' named entity 'Cutaneous' named entity 'SARS-CoV' named entity 'M2 macrophages' named entity 'M2 macrophages' named entity 'M2 macrophages' named entity 'c-Maf' named entity 'phenotype' named entity 'antigen retrieval' named entity 'fungus' named entity 'animal experiments' named entity 'infection' named entity 'immunomodulation' named entity 'aggressions' named entity 'macrophages' named entity 'bovine' named entity 'Arginase' named entity 'macrophages' named entity 'control group' named entity 'Hematoxylin-Eosin' named entity 'control group' named entity 'M1 macrophages' named entity 'immune response' named entity 'habitat' named entity 'morphology' named entity 'immune response' named entity 'citrate' named entity 'statistical difference' named entity 'Th1' named entity 'infectious diseases' named entity 'control group' named entity 'control group' named entity 'NF-kB' named entity 'stratum corneum' named entity 'yeast' named entity 'CD163' named entity 'pro-inflammatory' named entity 'macrophages' named entity 'bacteria' named entity 'fibrosis' named entity 'Brazil'

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