About: Temporal dynamics of human respiratory and gut microbiomes during the course of COVID-19 in adults

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Temporal dynamics of human respiratory and gut microbiomes during the course of COVID-19 in adults
Creator	Zhang, Chiyu Zhang, Tao Jin, Xia Xu, Rong Zhang, Zhigang Cai, Weihua Lu, Renfei Wu, Qunfu Han, Xudong Yunnan,
Source	MedRxiv
abstract	SARS-CoV-2 infects multiple organs including the respiratory tract and gut. Whether regional microbiomes are disturbed significantly to affect the disease progression of COVID-19 is largely unknown. To address this question, we performed cross-sectional and longitudinal analyses of throat and anal swabs from 35 COVID-19 adults and 15 controls by 16S rRNA gene sequencing. The results allowed a partitioning of patients into 3-4 categories (I-IV) with distinct microbial community types in both sites. Lower-diversity community types often appeared in the early phase of COVID-19, and synchronous fast restoration of both the respiratory and gut microbiomes from early dysbiosis towards late near-normal was observed in 6/8 mild COVID-19 adult patients despite they had a relatively slow clinical recovery. The synchronous shift of the community types was associated with significantly positive bacterial interactions between the respiratory tract and gut, possibly along the airway-gut axis. These findings reveal previously unknown interactions between respiratory and gut microbiomes, and suggest that modulations of regional microbiota might help to improve the recovery from COVID-19 in adult patients.
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.1101/2020.07.21.20158758
has license	medrxiv
sha1sum (hex)	429efe5630c303492597dd9ff02df864cbac9931
schema:url	https://doi.org/10.1101/2020.07.21.20158758
resource representing a document's title	Temporal dynamics of human respiratory and gut microbiomes during the course of COVID-19 in adults
resource representing a document's body	covid:429efe5630c303492597dd9ff02df864cbac9931#body_text
is schema:about of	named entity 'observed' named entity 'performed' named entity 'adults' named entity 'COVID-19' named entity 'disease' named entity 'human' named entity '16S rRNA' named entity 'COVID-19' named entity 'types' named entity 'modulations' named entity 'respiratory' named entity 'microbiomes' named entity 'swabs' named entity 'interactions' named entity 'COVID-19' named entity 'respiratory tract' named entity 'COVID-19' named entity 'microbiomes' named entity '16S rRNA gene sequencing' named entity 'microbial community' named entity 'microbiomes' named entity 'microbiomes' named entity 'State Key Laboratory' named entity 'Temporal dynamics' named entity 'COVID-19 disease' named entity 'peer review' named entity 'gut microbiota' named entity 'Comamonadaceae' named entity 'microbiome' named entity 'medRxiv' named entity 'RNA' named entity 'Fusobacterium' named entity 'Rothia' named entity 'dysbiosis' named entity 'clinical symptoms' named entity 'lung' named entity 'microbial' named entity 'microbiota' named entity 'COVID-19 disease' named entity 'types III and IV' named entity 'medRxiv' named entity 'microbiome' named entity 'COVID-19 disease' named entity 'commensals' named entity 'bacteria' named entity 'Bacteroides' named entity 'gut microbiome' named entity 'COVID-19' named entity 'microbiome' named entity 'COVID-19' named entity 'normal microbiota' named entity 'pathogenic bacteria' named entity 'CC-BY-NC-ND 4.0' named entity 'pathogenic bacteria' named entity 'medRxiv' named entity 'alpha diversity' named entity 'Pielou' named entity 'microbial' named entity 'genus' named entity 'microbial' named entity 'medRxiv' named entity 'infection' named entity 'microbiome' named entity 'Rothia' named entity 'medRxiv' named entity 'gut microbiota' named entity 'microbial' named entity 'COVID-19' named entity 'pathogenic bacteria' named entity 'Pseudomonas' named entity 'human diseases' named entity 'medRxiv' named entity 'COVID-19' named entity 'Laplace approximation' named entity 'ANOSIM' named entity 'types III and IV'

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