About: The Role of Viral Infection in Pulmonary Exacerbations of Bronchiectasis in Adults A Prospective Study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The Role of Viral Infection in Pulmonary Exacerbations of Bronchiectasis in Adults A Prospective Study
Creator	Gao, Yang Xu, Gang Zhong, Nan-Shan Tang, Yan Guan, Wei-Jie Chen, Rong-Chang Gao, Yong-Hua Li, Hui-Min Lin, Zhi-Min Lin, Zhi-Ya Zhang, Guo-Jun
source	Elsevier; Medline; PMC
abstract	BACKGROUND Although viral infections are a major cause of exacerbations in patients with chronic airway diseases, their roles in triggering bronchiectasis exacerbations in adults remain unclear. Therefore, we prospectively investigated the incidence and clinical impacts of viral infection in adults with bronchiectasis exacerbations. METHODS The study cohort of 119 adults with bronchiectasis was followed up prospectively for 12 months. Nasopharyngeal swabs and sputum samples were assayed for 16 respiratory viruses, using polymerase chain reaction assays. Symptoms, spirometry, quality of life, bacterial cultures, and inflammatory markers were assessed during steady-state bronchiectasis and exacerbations. RESULTS A total of 100 exacerbations were captured from 58 patients during 1-year follow-up. Respiratory viruses were found more frequently in nasopharyngeal swabs and sputum during bronchiectasis exacerbations (49 of 100, 49.0') than during steady state (11 of 58, 18.9'; P < .001). The most common viruses found in patients experiencing exacerbations were coronavirus (19 of 65, 39.2'), rhinovirus (16 of 65, 24.6'), and influenza A/B viruses (16 of 65, 24.6'). Virus-positive exacerbations were associated with a greater increase in markers of systemic and airway inflammation (serum IL-6 and tumor necrosis factor-α; sputum IL-1β and tumor necrosis factor-α) compared with virus-negative exacerbations, but the differences in spirometric indexes, quality of life, and bacterial density were unremarkable. In receiver operating characteristics analysis, serum interferon-γ-induced protein 10 yielded an area under curve of 0.67 (95' CI, 0.53-0.77; P = .018). Furthermore, a greater proportion of patients with virus-positive exacerbations received IV antibiotics. CONCLUSIONS Prevalence of viral infections, detected by polymerase chain reaction assay, is higher in cases of bronchiectasis exacerbations than in steady-state bronchiectasis, suggesting that respiratory viruses play crucial roles in triggering bronchiectasis exacerbations. The potential mechanisms of virus-induced bronchiectasis exacerbations merit further investigations. TRIAL REGISTRY ClinicalTrials.gov; No.: NCT01801657; www.clinicaltrials.gov
has issue date	2015-06-30(xsd:dateTime)
bibo:doi	10.1378/chest.14-1961
bibo:pmid	25412225
has license	els-covid
sha1sum (hex)	426ec923c79fbd5ad2af6af66343f3500d70354c
schema:url	https://doi.org/10.1378/chest.14-1961
resource representing a document's title	The Role of Viral Infection in Pulmonary Exacerbations of Bronchiectasis in Adults A Prospective Study
has PubMed Central identifier	PMC7094490
has PubMed identifier	25412225
schema:publication	Chest
resource representing a document's body	covid:426ec923c79fbd5ad2af6af66343f3500d70354c#body_text
is schema:about of	named entity 'ADULTS' named entity 'ROLE' named entity 'VIRAL INFECTIONS' named entity 'CAUSE' named entity 'VIRAL INFECTION' named entity 'INVESTIGATED' named entity 'PULMONARY' named entity 'ADULTS' named entity 'IMPACTS' named entity 'BRONCHIECTASIS' named entity 'VIRAL INFECTION' named entity 'BRONCHIECTASIS' named entity 'CHRONIC' named entity 'A MAJOR' named entity 'CLINICAL' named entity 'TRIGGERING' named entity 'INCIDENCE' named entity 'THEIR' named entity 'BACKGROUND' named entity 'ROLES' named entity 'AIRWAY DISEASES' named entity 'UNCLEAR' named entity 'PROSPECTIVE STUDY' named entity 'PATIENTS' covid:arg/426ec923c79fbd5ad2af6af66343f3500d70354c named entity 'chronic' named entity 'viral infections' named entity 'viral infection' named entity 'bronchiectasis' named entity 'Exacerbations' named entity 'Bronchiectasis' named entity 'QoL' named entity 'Mann-Whitney' named entity 'lung function' named entity 'viral infection' named entity 'dyspnea' named entity 'BEs' named entity 'quality of life' named entity 'bronchiectasis' named entity 'IL-6' named entity 'cough' named entity 'W. G.' named entity 'IP-10' named entity 'protein' named entity 'BMI' named entity 'follow-up' named entity 'virus' named entity 'British Thoracic Society' named entity 'nucleic acids' named entity 'virus' named entity 'bronchiectasis' named entity 'idiopathic' named entity 'Pseudomonas aeruginosa' named entity 'asthma' named entity 'BEs' named entity 'hemoptysis' named entity 'viruses' named entity 'viruses' named entity 'viruses' named entity 'virus' named entity 'viruses' named entity 'BEs' named entity 'lung function' named entity 'bronchiectasis' named entity 'Serum' named entity 'viruses' named entity 'viral infections' named entity 'Kruskal-Wallis test' named entity 'virus' named entity 'pathophysiologic mechanisms' named entity 'bronchiectasis'

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