About: Flavonoids and Their Biological Secrets

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Flavonoids and Their Biological Secrets
Creator	Rashid, H Ali, R Aziz, H Ehsan, N Fareed, M Ghaffar, I Gul, A Khalid, S Rashid, M Rehman, Khalid
Source	PMC
abstract	Flavonoids are tricyclic polyphenolic compounds naturally occurring in plants. Being nature’s antioxidants flavonoids have been shown to reduce the damages induced by oxidative stress in cells. Besides being an antioxidant, flavonols are demonstrated to have anti-infective properties, i.e., antiviral, antifungal, anti-angiogenic, anti-tumorigenic, and immunomodulatory bioproperties. Plants use them as one of their defense mechanisms against radiation-induced DNA damage and also for fungal infections. The use of flavonols for fabrication of new drugs has been underway with objectives to develop safer and effective therapeutic agents. This review covers 15 flavonols for their structure, biological properties, role in plant metabolisms, and current research focused on computational drug design using flavonols for searching drug leads.
has issue date	2019-01-23(xsd:dateTime)
bibo:doi	10.1007/978-3-030-03344-6_24
has license	no-cc
sha1sum (hex)	426d5d9f9e2dd6e6842f36ee1b472b51ee23df1c
schema:url	https://doi.org/10.1007/978-3-030-03344-6_24
resource representing a document's title	Flavonoids and Their Biological Secrets
has PubMed Central identifier	PMC7123471
schema:publication	Plant and Human Health, Volume 2
resource representing a document's body	covid:426d5d9f9e2dd6e6842f36ee1b472b51ee23df1c#body_text
is schema:about of	named entity 'PLANT' named entity 'HUMAN HEALTH' named entity 'macrophages' named entity 'chemopreventive' named entity 'antioxidant' named entity 'human gut' named entity 'beta-catenin' named entity 'Topoisomerase' named entity 'tumor cell lines' named entity 'antihypertensive' named entity 'sugar residues' named entity 'histamine' named entity 'S-adenosylhomocysteine' named entity 'CYP2D6' named entity 'p38 MAPK' named entity 'degranulation' named entity 'clinical trials' named entity 'tangerine' named entity 'prostaglandin E2' named entity 'hydrolysis' named entity 'tumorigenic' named entity 'excitotoxicity' named entity 'flavonoids' named entity 'inhibit the growth' named entity 'Citrus natsudaidai' named entity 'fungal infections' named entity 'Hibiscus' named entity 'molecule' named entity 'robinin' named entity 'Lactobacillus fermentum' named entity 'Oxidase' named entity 'cyclooxygenase-2' named entity 'polyphenols' named entity 'rat' named entity 'regulatory mechanisms' named entity 'Natsudaidain' named entity 'Antiallergenic' named entity 'diabetes mellitus' named entity 'NF-kappa B' named entity 'DMBA' named entity 'antiestrogenic' named entity 'small intestine' named entity 'galangin' named entity 'macrophage' named entity 'plant leaves' named entity 'DNA replication' named entity 'widely distributed' named entity 'circular dichroism' named entity 'nuclei' named entity 'papillary muscle' named entity 'quercetin' named entity 'acute inflammation' named entity 'neurological disorders' named entity 'Kaempferol' named entity 'polyphenols' named entity 'pentamethyl' named entity 'flavonols' named entity 'oxidative stress' named entity 'cloves' named entity 'anticarcinogenic' named entity 'protein' named entity 'mice' named entity 'gene expression' named entity 'liver' named entity 'chondrocytes' named entity 'sulfate' named entity 'flavonol' named entity 'liver cancer' named entity 'anti-angiogenic' named entity 'fisetin' named entity 'biological effects' named entity 'propolis' named entity 'chromatographic' named entity 'dose-dependent manner'

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