About: Identification and function analysis of canine stimulator of interferon gene (STING)

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About: Identification and function analysis of canine stimulator of interferon gene (STING) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification and function analysis of canine stimulator of interferon gene (STING)
Creator	Su, Shuo Gu, Jinyan Hu, Boli Lei, Jing Li, Gairu Liu, Fei Liu, Jie Shi, Zhiyu Sun, Haifeng Wang, Ruyi Xing, Gang Yan, Liping Zhai, Xiaofeng Zhang, Junyan Zhang, Yuxiang Zhou, Jiyong Zhu, Mengyan
Source	Elsevier; Medline; PMC
abstract	Abstract Stimulator of interferon gene (STING) plays an important role in the cyclic GMP-AMP synthase (cGAS)-mediated activation of type I IFN responses. In this study, we identified and cloned canine STING gene. Full-length STING encodes a 375 amino acid product that shares the highest similarity with feline STING. Highest levels of mRNA of canine STING were detected in the spleen and lungs while the lowest levels in the heart and muscle. Analysis of its cellular localization showed that STING is localizes to the endoplasmic reticulum. STING overexpression induced the IFN response via the IRF3 and NF-κB pathways and up-regulated the expression of ISG15 and viperin. However, knockdown of STING did not inhibit the IFN-β response triggered by poly(dA:dT), poly(I:C), or SeV. Finally, overexpression of STING significantly inhibited the replication of canine influenza virus H3N2. Collectively, our findings indicate that STING is involved in the regulation of the IFN-β pathway in canine.
has issue date	2017-12-31(xsd:dateTime)
bibo:doi	10.1016/j.micpath.2017.10.047
bibo:pmid	29074428
has license	els-covid
sha1sum (hex)	4208e8bddf6d5bf0d1baa10519b9cb2f27821a5f
schema:url	https://doi.org/10.1016/j.micpath.2017.10.047
resource representing a document's title	Identification and function analysis of canine stimulator of interferon gene (STING)
has PubMed Central identifier	PMC7127566
has PubMed identifier	29074428
schema:publication	Microbial Pathogenesis
resource representing a document's body	covid:4208e8bddf6d5bf0d1baa10519b9cb2f27821a5f#body_text
is schema:about of	named entity 'STIMULATOR' named entity 'gene' named entity 'type I IFN' named entity 'localization' named entity 'canine' named entity 'canine' named entity 'GENE' named entity 'POLY' named entity 'CANINE INFLUENZA VIRUS' named entity 'INVOLVED' named entity 'STING' named entity 'TYPE I' named entity 'HIGHEST' named entity 'STIMULATOR' named entity 'CELLULAR LOCALIZATION' named entity 'ITS' named entity 'ENDOPLASMIC RETICULUM' named entity 'DID' named entity 'ANALYSIS' named entity 'SEV' named entity 'FINDINGS' named entity 'BAB' named entity 'GENE' named entity 'PRODUCT' named entity 'OUR' named entity 'INHIBITED' named entity 'MEDIATED' named entity 'LEVELS' named entity 'LOWEST' named entity 'RESPONSE' covid:arg/4208e8bddf6d5bf0d1baa10519b9cb2f27821a5f named entity 'FUNCTION ANALYSIS' named entity 'INTERFERON ' named entity 'IDENTIFIED' named entity 'REPLICATION' named entity 'CANINE' named entity 'LENGTH' named entity 'AMINO ACID' named entity 'IMPORTANT' named entity '28I' named entity 'TRIGGERED BY' named entity 'MUSCLE' named entity 'PATHWAYS' named entity 'CLONED' named entity 'RESPONSES' named entity 'UP-REGULATED' named entity 'CANINE' named entity 'IDENTIFICATION' named entity 'SPLEEN' named entity 'ISG15' named entity 'EXPRESSION' named entity 'IRF3' named entity 'INDUCED' named entity 'FELINE' named entity 'SHARES' named entity 'ROLE' named entity 'PLAYS' named entity 'VIPERIN' named entity 'STUDY' named entity 'DETECTED' named entity 'REGULATION' named entity 'LUNGS' named entity 'ACTIVATION' named entity 'SIMILARITY' named entity 'HEART'

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