About: Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus

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About: Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus
Creator	Cao, Yongchang Xue, Chunyi Wang, Wei Li, Ran Li, Xiaoming Liu, Genmei Liu, Qiliang Lv, Lishan Shen, Huifang
source	Medline; PMC
abstract	Infectious bronchitis virus (IBV) poses a severe threat to the poultry industry and causes heavy economic losses worldwide. Vaccination is the most effective method of preventing infection and controlling the spread of IBV, but currently available inactivated and attenuated virus vaccines have some disadvantages. We developed a chimeric virus-like particle (VLP)-based candidate vaccine for IBV protection. The chimeric VLP was composed of matrix 1 protein from avian influenza H5N1 virus and a fusion protein neuraminidase (NA)/spike 1 (S1) that was generated by fusing IBV S1 protein to the cytoplasmic and transmembrane domains of NA protein of avian influenza H5N1 virus. The chimeric VLPs elicited significantly higher S1-specific antibody responses in intramuscularly immunized mice and chickens than inactivated IBV viruses. Furthermore, the chimeric VLPs induced significantly higher neutralization antibody levels than inactivated H120 virus in SPF chickens. Finally, the chimeric VLPs induced significantly higher IL-4 production in mice. These results demonstrate that chimeric VLPs have the potential for use in vaccines against IBV infection.
has issue date	2014-06-16(xsd:dateTime)
bibo:doi	10.4142/jvs.2014.15.2.209
bibo:pmid	24378590
has license	cc-by-nc
sha1sum (hex)	41deae1169912161f5195d978626aa2ca1898994
schema:url	https://doi.org/10.4142/jvs.2014.15.2.209
resource representing a document's title	Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus
has PubMed Central identifier	PMC4087222
has PubMed identifier	24378590
schema:publication	J Vet Sci
resource representing a document's body	covid:41deae1169912161f5195d978626aa2ca1898994#body_text
is schema:about of	named entity 'TRANSMEMBRANE' named entity 'CONTROLLING' named entity 'BUT' named entity 'SPF' named entity 'CHIMERIC VIRUS' named entity 'LEVELS' named entity 'HIGHER' named entity 'USE' named entity 'SPECIFIC ANTIBODY' named entity 'VLPS' named entity 'INACTIVATED' named entity 'VIRUS-LIKE PARTICLE' named entity 'FUSING' named entity 'GENERATED' named entity 'VACCINE' named entity 'RESULTS' named entity 'INDUCED' named entity 'METHOD' named entity 'PROTECTION' named entity 'VACCINATION' named entity 'chimeric' named entity 'chimeric' named entity 'immunized' named entity 'virus' named entity 'neuraminidase' named entity 'IBV' named entity 'chimeric' named entity 'FUSION PROTEIN' named entity 'EFFECTIVE' named entity 'RESPONSES' named entity 'VIRUS' named entity 'CANDIDATE' named entity 'CYTOPLASMIC' named entity 'CHICKENS' named entity 'VACCINES' named entity 'POTENTIAL' named entity 'NEURAMINIDASE' named entity 'CHIMERIC' named entity 'VLP' named entity 'H5N1 VIRUS' named entity 'PROTEIN ' named entity 'ANTIBODY' named entity 'THESE' named entity 'COMPOSED OF' named entity 'VETERINARY SCIENCE' named entity 'IBV' named entity 'SPREAD' named entity 'PREVENTING' named entity 'MICE' named entity 'IMMUNIZED' named entity 'IL-4 PRODUCTION' named entity 'AVIAN INFLUENZA' named entity 'HAVE' named entity 'MATRIX' named entity 'CURRENTLY' named entity 'ATTENUATED' named entity 'ELICITED' named entity 'INFECTION' named entity 'AVAILABLE' named entity 'BASED' named entity 'VIRUSES' covid:arg/41deae1169912161f5195d978626aa2ca1898994 named entity 'fusing' named entity 'virus' named entity 'H5N1' named entity 'matrix' named entity 'vaccine' named entity 'antibody' named entity 'higher' named entity 'protein' named entity 'IL-4' named entity 'virus-like particle' named entity 'chimeric'

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