About: Inevitable isolation and the change of stress markers in hemodialysis patients during the 2015 MERS-CoV outbreak in Korea

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About: Inevitable isolation and the change of stress markers in hemodialysis patients during the 2015 MERS-CoV outbreak in Korea Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Inevitable isolation and the change of stress markers in hemodialysis patients during the 2015 MERS-CoV outbreak in Korea
Creator	Lee, Young-Ki Lee, Sang-Ho Jeong, Da-Wun Cho, Ajin Kim, Kipyo Kim, Se-Yun Kim, Yang Lee, Hong-Seock Lee, Yu-Ho Moon, Haena Moon, Ju Cho Park, Hayne
Source	Medline; PMC
abstract	During the outbreak of Middle East respiratory syndrome coronavirus(MERS-CoV) in 2015, one hemodialysis patient was infected with MERS-CoV, and the remaining hemodialysis(HD) patients (n = 83) and medical staff (n = 12) had to undergo dialysis treatment in an isolated environment. This study was performed to investigate the effects of stress caused by dialysis treatment under isolation. Plasma samples from the HD patients and medical staff were collected at the time of isolation(M0), the following month(M1), and three months after isolation(M3). Parameters for stress included circulating cell-free genomic DNA(ccf-gDNA), circulating cell-free mitochondria DNA(ccf-mtDNA), and pentraxin-3(PTX-3). Decreased values of Hct, kt/v and ca x p were recovered after the end of two weeks of isolation. The levels of ccf-gDNA and ccf-mtDNA were the highest at M0 and decreased gradually in both HD patients and the medical staff. The normalization of ccf-gDNA and ccf-mtDNA was significantly delayed in HD patients compared with the response in the medical staff. PTX-3 increased only in HD patients and was highest at M0, and it then gradually decreased. Medical isolation and subnormal quality of care during the MERS outbreak caused extreme stress in HD patients. Plasma cell-free DNA and PTX-3 seems to be good indicators of stress and quality of care in HD patients.
has issue date	2019-04-05(xsd:dateTime)
bibo:doi	10.1038/s41598-019-41964-x
bibo:pmid	30952879
has license	cc-by
sha1sum (hex)	418826a231c08bed06a47bd7d0b96dcdf66bd3e6
schema:url	https://doi.org/10.1038/s41598-019-41964-x
resource representing a document's title	Inevitable isolation and the change of stress markers in hemodialysis patients during the 2015 MERS-CoV outbreak in Korea
has PubMed Central identifier	PMC6450937
has PubMed identifier	30952879
schema:publication	Sci Rep
resource representing a document's body	covid:418826a231c08bed06a47bd7d0b96dcdf66bd3e6#body_text
is schema:about of	named entity 'KOREA' named entity 'OPEN' named entity 'OUTBREAK' named entity 'USING' named entity 'TO INVESTIGATE' named entity 'SAMPLES' named entity 'REAL-TIME PCR ' named entity 'SYSTEM' named entity 'HIGHEST' named entity 'MARKERS' named entity 'ISOLATION' named entity 'NORMALIZATION' named entity 'PERFORMED' named entity 'DILUTED' named entity 'EFFECTS' named entity 'CALIF' named entity 'EXTREME' named entity 'TECHNOLOGIES' named entity 'MERS' named entity 'TREATMENT' named entity 'DUPLICATE' named entity 'LEVELS' named entity 'VALUES' named entity 'INCLUDED' named entity 'ANALYSIS' named entity 'FREE' named entity 'GENOMIC DNA' named entity 'FRAGMENTS' named entity 'PENTRAXIN-3' named entity 'AMPLIFIED' named entity 'ISOLATED ENVIRONMENT' named entity 'THE CHANGE' named entity 'CIRCULATING' named entity 'HCT' named entity 'STRESS' named entity 'MERS- COV' named entity 'PATIENTS' named entity 'ISOLATION' named entity 'HEMODIALYSIS' named entity 'STRESS' named entity 'STUDY' named entity 'INTEGRATED' named entity 'PRIMERS' named entity 'CELL' named entity 'MITOCHONDRIA DNA' named entity 'OUTBREAK' named entity 'DNA' named entity 'GENE' named entity 'PTX' named entity 'ABSOLUTE' named entity 'PLASMA' named entity 'GOOD' named entity 'ND1' named entity 'MTDNA' named entity 'KIT' named entity 'INDICATORS' named entity 'MEDICAL STAFF' named entity 'GDNA' named entity 'VALENCIA' named entity 'TEMPLATE' named entity 'MONTH' named entity 'DECREASED' named entity 'MASSACHUSETTS' named entity 'DELAYED' named entity 'QUALITY OF CARE' named entity 'ANALYZED' named entity 'PATIENTS' named entity 'QUANTIFICATION' named entity 'LIPOPROTEIN LIPASE GENE' named entity 'FOLLOWING'

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