About: Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis.

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About: Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis.
Creator	Affiliations, Chroboczek, Tomasz Amar, Benjamin Boisson, Thomas Challan-Belval, Thibaut Dechaene, Victor Hubac, Jason Lacoste, Marie Lassale, Camille Leduc, Dominique Masse, Colleen Megessier, Sandrine Touhiri-Maximin, Laetitia Wackenheim, Chloe
source	MedRxiv
abstract	Background. Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), is spreading worldwide, causing significant morbidity and mortality. No specific treatment has yet clearly shown to improve the disease's evolution. Validated therapeutic options are urgently needed. Methods. In this retrospective study, we aimed to evaluate determinants of the prognosis of the disease in 70 patients with COVID-19 severe pneumonia (i.e. requiring at least 3 liters of oxygen) hospitalized between 10 March and 9 April, 2020, in the Centre Hospitalier Alpes Leman, France. The main outcome was oro-tracheal intubation and the exposure of interest was corticotherapy. Since this was not a randomized trial, we used propensity score matching to estimate average treatment effect. Results. There was evidence that corticotherapy lowered the risk of intubation with a risk difference of -47.1% (95% confidence interval -71.8% to -22.5%). Conclusion. Corticosteroid, a well-known, easily available, and cheap treatment, could be an important tool in management of severe COVID-19 patients with respiratory failure. Not only could it provide an individual benefit, but also, in the setting of the COVID-19 ongoing pandemic, lower the burden on our vulnerable healthcare systems.
has issue date	2020-05-13(xsd:dateTime)
bibo:doi	10.1101/2020.05.08.20094755
has license	medrxiv
sha1sum (hex)	41606dee9c6205fd5ffe8c5b270c034e5aa19039
schema:url	https://doi.org/10.1101/2020.05.08.20094755
resource representing a document's title	Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis.
resource representing a document's body	covid:41606dee9c6205fd5ffe8c5b270c034e5aa19039#body_text
is schema:about of	named entity 'Contribution' named entity 'authors' named entity 'preprint' named entity 'pneumonia' named entity 'corticosteroids' named entity 'COVID-19' named entity 'propensity score matching' named entity 'WORK' named entity 'medRxiv' named entity 'Beneficial effect' named entity 'preprint' named entity 'pneumonia' named entity 'APPROVED' named entity 'MANUSCRIPT' named entity 'MATCHING' covid:arg/41606dee9c6205fd5ffe8c5b270c034e5aa19039 named entity 'manuscript' named entity 'CORTICOSTEROIDS' named entity 'TITLE' named entity 'manuscript' named entity 'severe' named entity 'corticosteroids' named entity 'AUTHORS' named entity 'CONTRIBUTION' named entity 'propensity score matching' named entity 'COVID-19' named entity 'Title' named entity 'Beneficial' named entity 'ANALYSIS' named entity 'BENEFICIAL EFFECT' named entity 'PREPRINT' named entity 'SEEN' named entity 'HAVE' named entity 'SEVERE COVID-19' named entity 'COVID-19 PNEUMONIA' named entity 'PROPENSITY SCORE' nodeID://b56162450 nodeID://b56193730 nodeID://b56293602 nodeID://b56302358 nodeID://b56358302 nodeID://b56852334 nodeID://b57267238 nodeID://b57404954 nodeID://b57530854
is wasQuotedFrom of	covid:arg/41606dee9c6205fd5ffe8c5b270c034e5aa19039/0
is part of of	Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. Background. Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), is spreading worldwide, causing significant morbidity and mortality. No specific treatment has yet clearly shown to improve the disease's evolution. Validated therapeutic options are urgently needed. Methods. In this retrospective study, we aimed to evaluate determinants of the prognosis of the disease in 70 patients with COVID-19 severe pneumonia (i.e. requiring at least 3 liters of oxygen) hospitalized between 10 March and 9 April, 2020, in the Centre Hospitalier Alpes Leman, France. The main outcome was oro-tracheal intubation and the exposure of interest was corticotherapy. Since this was not a randomized trial, we used propensity score matching to estimate average treatment effect. Results. There was evidence that corticotherapy lowered the risk of intubation with a risk difference of -47.1% (95% confidence interval -71.8% to -22.5%). Conclusion. Corticosteroid, a well-known, easily available, and cheap treatment, could be an important tool in management of severe COVID-19 patients with respiratory failure. Not only could it provide an individual benefit, but also, in the setting of the COVID-19 ongoing pandemic, lower the burden on our vulnerable healthcare systems. covid:41606dee9c6205fd5ffe8c5b270c034e5aa19039#body_text

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