About: Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates
Creator	Zhang, Xue Zhu, Ying Wu, Jianguo Li, Yan Yan, Huimin Xiao, Gengfu Wu, Kailang Guo, Deyin Zheng, Congyi Zhang, Jianlin Liu, M Zhang, Jiamin Wang, K Gu, Chunfang Zhao, Weiguang
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) caused by SARS-associated coronavirus (SARS-CoV) is a fatal disease. Prevention of future outbreaks is essential and requires understanding pathogenesis and evolution of the virus. We have isolated a SARS-CoV in China and analyzed 47 SARS-CoV genomes with the aims to reveal the evolution trends of the virus and provide insights into understanding pathogenesis and SARS epidemic. Specimen from a SARS patient was inoculated into cell culture. The presence of SARS-CoV was determined by RT-PCR and confirmed by electron microscopy. Virus was isolated followed by the determination of its genome sequences, which were then analyzed by comparing with other 46 SARS-CoV genomes. Genetic mutations with potential implications to pathogenesis and the epidemic were characterized. This viral genome consists of 29,728 nucleotides with overall organization in agreement with that of published isolates. A total of 348 positions were mutated on 47 viral genomes. Among them 22 had mutations in more than three genomes. Hot spots of nucleotide variations and unique trends of mutations were identified on the viral genomes. Mutation rates were different from gene to gene and were correlated well with periodical or geographic characteristics of the epidemic.
has issue date	2005-01-01(xsd:dateTime)
bibo:doi	10.1007/s11262-004-4586-9
bibo:pmid	15744567
has license	no-cc
sha1sum (hex)	414fe4bb5c58ce72970c1ed74f397c3782ccf083
schema:url	https://doi.org/10.1007/s11262-004-4586-9
resource representing a document's title	Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates
has PubMed Central identifier	PMC7089183
has PubMed identifier	15744567
schema:publication	Virus Genes
resource representing a document's body	covid:414fe4bb5c58ce72970c1ed74f397c3782ccf083#body_text
is schema:about of	named entity 'Specimen' named entity 'Severe acute respiratory syndrome (SARS)' named entity 'viral genomes' named entity 'SARS-CoV' named entity 'periodical' named entity 'isolated' named entity 'geographic' named entity 'PATIENT' named entity 'PATHOGENESIS' named entity 'VIRUS' named entity 'ITS' named entity 'ELECTRON MICROSCOPY' named entity 'NUCLEOTIDES' named entity 'COMPARING' named entity 'VIRUS' named entity 'POTENTIAL' named entity 'DIFFERENT' named entity 'IS A' named entity 'EPIDEMIC' named entity 'SARS-COV' named entity 'MUTATIONS' named entity 'GENE' named entity 'FOLLOWED BY' named entity 'DETERMINED BY' named entity 'PATIENT' named entity 'ISOLATES' named entity 'MORE THAN' named entity 'CHARACTERIZED' named entity 'IDENTIFIED' named entity 'UNIQUE' named entity 'HAVE' named entity 'ANALYZED' named entity 'GENOME' named entity 'FATAL DISEASE' named entity 'VIRAL GENOME' named entity 'RT-PCR' named entity 'AIMS' named entity 'OUTBREAKS' named entity 'INSIGHTS' named entity 'VARIATIONS' named entity 'SARS' named entity 'PATHOGENESIS' named entity 'VIRAL' named entity 'CHARACTERISTICS' named entity 'CHINA' named entity 'CORRELATED' named entity 'AGREEMENT' named entity 'CAUSED BY' named entity 'SEQUENCES' named entity 'SPECIMEN' named entity 'SARS' named entity 'MUTATED' named entity 'REVEAL' named entity 'PRESENCE OF' named entity 'UNDERSTANDING' named entity 'CELL CULTURE' named entity 'PREVENTION OF' named entity 'FUTURE' named entity 'ISOLATES' named entity 'EPIDEMIOLOGY' named entity 'ISOLATION' named entity 'SARS-COV' named entity 'GEOGRAPHIC' named entity 'PROVIDE' named entity 'OVERALL' named entity 'TRENDS' named entity 'GENETIC MUTATIONS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software