About: Transient virus infection and multiple sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transient virus infection and multiple sclerosis
Creator	Atkins, G Sheahan, B Amor, S Cosby, S Galbraith, S Mcquaid, S Morris-Downes, M
Source	Medline; PMC
abstract	Multiple sclerosis (MS) is a chronic, demyelinating disease of the CNS in which autoimmunity to myelin plays a role in pathogenesis. The epidemiology of MS indicates that it may be triggered by a virus infection before the age of adolescence, but attempts to associate a specific virus with MS have produced equivocal results. Many studies of the aetiology of MS have postulated that a persistent virus infection is involved, but transient virus infection may provide a plausible alternative mechanism that could explain many of the inconsistencies in MS research. The most studied animal model of MS is chronic relapsing experimental autoimmune encephalomyelitis (CREAE), which is induced in susceptible animals following injection of myelin components. While CREAE cannot provide information on the initiating factor for MS, it may mimic disease processes occurring after an initial trigger that may involve transient virus infection. The disease process may comprise separate triggering and relapse phases. The triggering phase may involve sensitisation to myelin antigens as a result of damage to oligodendrocytes or molecular mimicry. The relapse phase could be similar to CREAE, or alternatively relapses may be induced by further transient virus infections which may not involve infection of the CNS, but which may involve the recrudescence of anti‐myelin autoimmunity. Although current vaccines have a high degree of biosafety, it is suggested that the measles‐mumps‐rubella vaccine in particular could be modified to obviate any possibility of triggering anti‐myelin autoimmunity. Copyright © 2000 John Wiley & Sons, Ltd.
has issue date	2000-09-28(xsd:dateTime)
bibo:doi	10.1002/1099-1654(200009/10)10:5<291::aid-rmv278>3.0.co;2-u
bibo:pmid	11015741
has license	no-cc
sha1sum (hex)	41032a4c57c396bc775aa59e13855ede5ce174c7
schema:url	https://doi.org/10.1002/1099-1654%28200009/10%2910:5%3C291::aid-rmv278%3E3.0.co%3B2-u
resource representing a document's title	Transient virus infection and multiple sclerosis
has PubMed Central identifier	PMC7169221
has PubMed identifier	11015741
schema:publication	Rev Med Virol
resource representing a document's body	covid:41032a4c57c396bc775aa59e13855ede5ce174c7#body_text
is schema:about of	named entity 'myelin' named entity 'disease' named entity 'phase' named entity 'process' named entity 'biosafety' named entity 'INFECTION' named entity 'PHASE' named entity 'INDUCED' named entity 'VIRUS INFECTION' named entity 'involve' named entity 'virus' named entity 'alternatively' named entity 'experimental autoimmune encephalomyelitis' named entity 'virus infection' named entity 'infection' named entity 'mice' named entity 'astrocytes' named entity 'Theiler's murine encephalomyelitis virus' named entity 'MMR vaccine' named entity 'vaccination' named entity 'TGF-b' named entity 'demyelination' named entity 'antigen' named entity 'viruses' named entity 'mice' named entity 'demyelination' named entity 'infection' named entity 'murine' named entity 'virus diseases' named entity 'biopsy' named entity 'secretion' named entity 'vaccine' named entity 'human endogenous retroviruses' named entity 'circumstantial evidence' named entity 'MBP' named entity 'mice' named entity 'virus infections' named entity 'MBP' named entity 'adolescence' named entity 'hepatitis B virus' named entity 'secretion' named entity 'vaccine strain' named entity 'MOG' named entity 'autopsy' named entity 'demyelination' named entity 'demyelination' named entity 'experimental autoimmune encephalomyelitis' named entity 'mice' named entity 'virus infection' named entity 'myelin' named entity 'brain parenchyma' named entity 'microglia' named entity 'antigens' named entity 'superantigens' named entity 'initial phase' named entity 'myelin' named entity 'developed countries' named entity 'cytokines' named entity 'immunological' named entity 'Measles, mumps and rubella' named entity 'CD8+ T-lymphocytes' named entity 'Th1' named entity 'initial phase' named entity 'Rubella virus' named entity 'infection' named entity 'demyelination' named entity 'infection' named entity 'measles virus' named entity 'MMR vaccine' named entity 'autoimmunity' named entity 'vaccination' named entity 'epiphenomenon' named entity 'EAE' named entity 'peptides' named entity 'infection'

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