About: A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques

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About: A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques
Creator	Munster, Vincent Feldmann, Friederike Bushmaker, Trenton Lambe, Teresa Saturday, Greg Fischer, Robert Okumura, Atsushi Haddock, Elaine Gilbert, Sarah Meade-White, Kimberly Edwards, Nick Hanley, Patrick Van Doremalen, Neeltje Clark, Madeleine
source	Medline; PMC
abstract	Developing a vaccine to protect against the lethal effects of the many strains of coronavirus is critical given the current global pandemic. For Middle East respiratory syndrome coronavirus (MERS-CoV), we show that rhesus macaques seroconverted rapidly after a single intramuscular vaccination with ChAdOx1 MERS. The vaccine protected against respiratory injury and pneumonia and reduced viral load in lung tissue by several orders of magnitude. MERS-CoV replication in type I and II pneumocytes of ChAdOx1 MERS–vaccinated animals was absent. A prime-boost regimen of ChAdOx1 MERS boosted antibody titers, and viral replication was completely absent from the respiratory tract tissue of these rhesus macaques. We also found that antibodies elicited by ChAdOx1 MERS in rhesus macaques neutralized six different MERS-CoV strains. Transgenic human dipeptidyl peptidase 4 mice vaccinated with ChAdOx1 MERS were completely protected against disease and lethality for all different MERS-CoV strains. The data support further clinical development of ChAdOx1 MERS.
has issue date	2020-06-10(xsd:dateTime)
bibo:doi	10.1126/sciadv.aba8399
bibo:pmid	32577525
has license	cc-by-nc
sha1sum (hex)	40ffaa8fc1c996484aabf87e7d3645fac8bdab43
schema:url	https://doi.org/10.1126/sciadv.aba8399
resource representing a document's title	A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques
has PubMed Central identifier	PMC7286676
has PubMed identifier	32577525
schema:publication	Sci Adv
resource representing a document's body	covid:40ffaa8fc1c996484aabf87e7d3645fac8bdab43#body_text
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