About: ASSOCIATION OF INITIAL VIRAL LOAD IN SARS-CoV-2 PATIENTS WITH OUTCOME AND SYMPTOMS

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ASSOCIATION OF INITIAL VIRAL LOAD IN SARS-CoV-2 PATIENTS WITH OUTCOME AND SYMPTOMS
Creator	Kim, Min Belovarac, Brendan Black, Margaret Cotzia, Paolo Feng, Xiaojun Heguy, Adriana Jour, George Lin, Lawrence Lytle, Andrew Moran, Una Osman, Iman Serrano, Antonio Shen, Guomiao Snuderl, Matija Troxel, Andrea Vougiouklakis, Theodore Argyropoulos, Kimon Call, Melissa Hu, Jiyuan
Source	Elsevier; Medline; PMC
abstract	The dynamics of viral load (VL) of the 2019 novel coronavirus (SARS-CoV-2) and its association with different clinical parameters remain poorly characterized in the United States patient population. Herein we investigate associations between VL and parameters such as severity of symptoms, disposition (admission vs direct discharge), length of hospitalization, and admission to the intensive care unit, length of need for oxygen support and overall survival in a cohort of 205 patients from a tertiary care center in New York City. VL was determined using q-PCR and Log10 transformed for normalization. Univariate and multivariate regression models were used to test these associations. We found that diagnostic viral load is significantly lower in hospitalized patients than in patients not hospitalized (log10 VL = 3.3 vs.4.0; p=0.018) after adjusting for age, sex, race, BMI, and comorbidities. Higher VL was associated with shorter duration of the symptoms in all patients and hospitalized patients only and shorter hospital stay (coefficient =-2.02,-2.61, -2.18; p<0.001, p=0.002, p=0.013, respectively). No significant association was noted between VL, admission to ICU, length of oxygen support, and overall survival. Our findings suggest a higher shedding risk in less symptomatic patients; an important consideration for containment strategies in SARS-CoV-2. Furthermore, we identify a novel association between viral load and history of cancer. Larger studies are warranted to validate our findings.
has issue date	2020-07-03(xsd:dateTime)
bibo:doi	10.1016/j.ajpath.2020.07.001
bibo:pmid	32628931
has license	no-cc
sha1sum (hex)	4049173c7dd1c8121691f00e02a8ef30957bcef0
schema:url	https://doi.org/10.1016/j.ajpath.2020.07.001
resource representing a document's title	ASSOCIATION OF INITIAL VIRAL LOAD IN SARS-CoV-2 PATIENTS WITH OUTCOME AND SYMPTOMS
has PubMed Central identifier	PMC7332909
has PubMed identifier	32628931
schema:publication	Am J Pathol
resource representing a document's body	covid:4049173c7dd1c8121691f00e02a8ef30957bcef0#body_text
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