About: Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state

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About: Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state
Creator	Saalmüller, Armin Gerner, Wilhelm Müllebner, Andrea Duvigneau, J Essler, Sabine Mair, Kerstin Storset, Anne
Source	Medline; PMC
abstract	Natural Killer (NK) cells play a crucial role in the early phase of immune responses against various pathogens. In swine so far only little information about this lymphocyte population exists. Phenotypical analyses with newly developed monoclonal antibodies (mAbs) against porcine NKp46 recently revealed that in blood NKp46(-) and NKp46(+) cells with NK phenotype exist with comparable cytotoxic properties. In spleen a third NKp46-defined population with NK phenotype was observed that was characterised by a low to negative CD8α and increased NKp46 expression. In the current study it is shown that this NKp46(high) phenotype was correlated with an increased expression of CD16 and CD27 compared to the CD8α(+)NKp46(-) and NKp46(+) NK-cell subsets in spleen and blood. Additionally NKp46(high) NK cells expressed elevated levels of the chemokine receptor CXCR3 on mRNA level. Functional analyses revealed that splenic NKp46(high) NK cells produced much higher levels of Interferon-γ and Tumor Necrosis Factor-α upon stimulation with cytokines or phorbol-12-myristate-13-acetate/Ionomycin compared to the other two subsets. Furthermore, cross-linking of NKp46 by NKp46-specific mAbs led to a superior CD107a expression in the NKp46(high) NK cells, thus indicating a higher cytolytic capacity of this subset. Therefore porcine splenic NKp46(high) NK cells represent a highly activated subset of NK cells and may play a profound role in the immune surveillance of this organ.
has issue date	2013-03-01(xsd:dateTime)
bibo:doi	10.1186/1297-9716-44-13
bibo:pmid	23452562
has license	cc-by
sha1sum (hex)	402334dfcf4430553c3f99a5bbe869a3882c1d97
schema:url	https://doi.org/10.1186/1297-9716-44-13
resource representing a document's title	Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state
has PubMed Central identifier	PMC3599810
has PubMed identifier	23452562
schema:publication	Vet Res
resource representing a document's body	covid:402334dfcf4430553c3f99a5bbe869a3882c1d97#body_text
is schema:about of	named entity 'levels' named entity 'phase' named entity 'Interferon-γ' named entity 'exists' named entity 'high' named entity 'subset' named entity 'expression' named entity 'NK cells' named entity 'compared' named entity 'observed' named entity 'phorbol' named entity 'STUDY' named entity 'NATURAL KILLER' named entity 'SWINE' covid:arg/402334dfcf4430553c3f99a5bbe869a3882c1d97 named entity 'ACTIVATED' named entity 'CORRELATED' named entity 'NKP46' named entity 'REPRESENT' named entity 'PROFOUND' named entity 'STATE' named entity 'NKP46' named entity 'LED' named entity 'CD8' named entity 'INTERFERON' named entity 'CURRENT' named entity 'PROPERTIES' named entity 'STIMULATION' named entity 'MRNA' named entity 'POPULATION' named entity 'RECENTLY' named entity 'SPLEEN' named entity 'NK-CELL' named entity 'ELEVATED' named entity 'IN BLOOD' named entity 'CD107A' named entity 'INCREASED EXPRESSION' named entity 'PORCINE' named entity 'CD16' named entity 'PHENOTYPE' named entity 'PORCINE' named entity 'CD8' named entity 'DIM' named entity 'HIGH' named entity 'CYTOTOXIC' named entity 'HIGH' named entity 'CELLS' named entity 'MUCH' named entity 'SUBSET' named entity 'CYTOKINES' named entity 'NEWLY' named entity 'VARIOUS' named entity 'IMMUNE RESPONSES' named entity 'MONOCLONAL ANTIBODIES' named entity 'NK CELLS' named entity 'CROSS-LINKING' named entity 'SPECIFIC' named entity 'NEGATIVE' named entity 'EXIST' named entity 'ROLE' named entity 'LITTLE' named entity 'ORGAN' named entity 'FUNCTIONAL' named entity 'ABOUT' named entity 'DEFINED' named entity 'SPLENIC' named entity 'OBSERVED' named entity 'SUPERIOR' named entity 'REVEALED' named entity 'LOW' named entity 'BLOOD' named entity 'TUMOR NECROSIS FACTOR' named entity 'LYMPHOCYTE' named entity 'IMMUNE SURVEILLANCE' named entity 'COMPARED'

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