About: Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation
Creator	Grissell, Terry Cameron, R Ferguson, John Rye, Peter Welsh, Toni Cameron Deo De Wit, Robert Ferguson, J Ferguson, · Grissell, · Rye, P Welsh, T
source	Medline; PMC
abstract	OBJECTIVES: We aimed to characterise and quantify the incidence of common infectious agents in acute exacerbations of chronic obstructive pulmonary disease (COPD) requiring ventilation, with a focus on respiratory viruses. DESIGN: An epidemiological study conducted over 3 years. SETTING: A 12-bed intensive care unit (ICU). PARTICIPANTS: ICU patients over 45 years of age with a primary diagnosis of COPD exacerbation requiring non-invasive ventilation (NIV) or ventilation via endotracheal tube (ETT). MATERIALS AND METHODS: Nasopharyngeal aspirates (NPA) and posterior pharyngeal swabs (PS) were tested for viruses with immunofluorescence assay (IFA), virus culture (VC) and polymerase chain reaction (PCR). Paired virus and atypical pneumonia serology assays were taken. Blood, sputum and endotracheal aspirates were cultured for bacteria. RESULTS: 107 episodes in 105 patients were recorded. Twenty-three (21%) died within 28 days. A probable infectious aetiology was found in 69 patient episodes (64%). A virus was identified in 46 cases (43%), being the sole organism in 35 cases (33%) and part of a mixed infection in 11 cases (10%). A probable bacterial aetiology was found in 25 cases (23%). There was no statistically significant difference in clinical characteristics or outcomes between the group with virus infections and that without. CONCLUSION: Forty-six (43%) of the patients with COPD exacerbation requiring mechanical ventilation had a probable viral pathogen. Prodromal, clinical and outcome parameters did not distinguish virus from non-virus illness. PCR was the most sensitive whilst virus culture was the least of virus assays. ELECTRONIC SUPPLEMENTARY MATERIAL: The electronic reference of this article is http://dx.doi.org/10.1007/s00134-006-0202-x. The online full-text version of this article includes electronic supplementary material. This material is available to authorised users and can be accessed by means of the ESM button beneath the abstract or in the structured full-text article. To cite or link to this article you can use the above reference.
has issue date	2006-05-24(xsd:dateTime)
bibo:doi	10.1007/s00134-006-0202-x
bibo:pmid	16791664
has license	no-cc
sha1sum (hex)	3ff32b1fa0ed3783d5c832fe72dbe261423933d4
schema:url	https://doi.org/10.1007/s00134-006-0202-x
resource representing a document's title	Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation
has PubMed Central identifier	PMC7080063
has PubMed identifier	16791664
schema:publication	Intensive Care Med
resource representing a document's body	covid:3ff32b1fa0ed3783d5c832fe72dbe261423933d4#body_text
is schema:about of	named entity 'BEING' named entity 'RESPIRATORY VIRUSES' named entity 'ILLNESS' named entity 'OUTCOMES' named entity 'INFECTIOUS' named entity 'DIFFERENCE' named entity 'CASES' named entity 'NASOPHARYNGEAL' covid:arg/3ff32b1fa0ed3783d5c832fe72dbe261423933d4 named entity 'INCIDENCE' named entity 'PATIENTS' named entity 'FORTY' named entity 'SENSITIVE' named entity 'ATYPICAL PNEUMONIA' named entity 'NON-INVASIVE VENTILATION' named entity 'BED' named entity 'PARAMETERS' named entity 'INFECTIONS' named entity 'VIRUS' named entity 'IMMUNOFLUORESCENCE ASSAY' named entity 'PAIRED' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'ORGANISM' named entity 'INTENSIVE CARE UNIT' named entity 'OBJECTIVES' named entity 'GROUP' named entity 'FOUND' named entity 'MIXED INFECTION' named entity 'ACUTE EXACERBATIONS' named entity 'VIRUS INFECTION' named entity '105' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'YEARS' named entity 'SPUTUM' named entity 'COMMON' named entity 'RECORDED' named entity 'MECHANICAL VENTILATION' named entity 'ICU' named entity 'VENTILATION' named entity 'N A' named entity 'TAKEN' named entity 'POLYMERASE CHAIN REACTION' named entity 'TESTED FOR' named entity 'POSTERIOR' named entity 'DIED' named entity 'VENTILATION' named entity 'PARTICIPANTS' named entity 'CLINICAL' named entity 'CONCLUSION' named entity 'EPISODES' named entity 'PCR' named entity 'PRODROMAL' named entity 'BACTERIA.' named entity '107' named entity 'PRIMARY DIAGNOSIS' named entity 'AETIOLOGY' named entity 'DID' named entity 'VIRUSES' named entity 'PROBABLE' named entity 'ENDOTRACHEAL' named entity 'FOCUS' named entity 'STATISTICALLY SIGNIFICANT' named entity 'OUTCOME' named entity 'CULTURED' named entity 'PART OF' named entity 'PATIENT' named entity 'TWENTY-THREE' named entity 'DAYS' named entity 'VIA ENDOTRACHEAL TUBE' named entity 'BACTERIAL' named entity 'PHARYNGEAL'

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