About: Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue
Creator	Wong, Man Gershkovich, Pavel Chi, Jonathan Gershkovich, P Pharm, Clin Wong, • Zgair, A Zgair, Atheer
Source	PMC
abstract	In addition to fluid haemostasis and lipid absorption, the lymphatic system and lymphoid tissues serve as the major host of immune cells where immune responses are evoked. Impaired function of the immune system might lead to serious diseases which are often treated by immunomodulators. This chapter briefly explores the physiology of an important part of the lymphatic system, the gut-associated lymphoid tissues (GALT). Currently used strategies for targeting GALT by immunomodulators for enhanced activity and/or decreased side effects are discussed. Strategies range from simple oral co-administration of immunomodulators with lipids to more advanced lipid-based formulations, polymer-based nanoparticle formulations and prodrugs. These targeting approaches successfully increase the concentration of immunomodulators achieved in the GALT and, more importantly, enhance immunomodulatory effects. Therefore, targeting immunomodulators to GALT represent a promising approach in the treatment of diseases where the immune system is actively involved.
has issue date	2016-05-25(xsd:dateTime)
bibo:doi	10.1007/978-3-319-28609-9_14
has license	no-cc
sha1sum (hex)	3ff014a8bda72130f2d8ba4a7984cca172bc4000
schema:url	https://doi.org/10.1007/978-3-319-28609-9_14
resource representing a document's title	Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue
has PubMed Central identifier	PMC7123898
schema:publication	Neuro-Immuno-Gastroenterology
resource representing a document's body	covid:3ff014a8bda72130f2d8ba4a7984cca172bc4000#body_text
is schema:about of	named entity 'lymphatic system' named entity 'immunomodulators' named entity 'targeting' named entity 'addition' named entity 'THE GUT' named entity 'INVOLVED' named entity 'MAJOR' named entity 'ADMINISTRATION' named entity 'EVOKED' named entity 'THESE' named entity 'PART OF' named entity 'ENHANCE' named entity 'STRATEGIES' named entity 'LIPID ABSORPTION' named entity 'APPROACHES' named entity 'LIPID' named entity 'GUT-ASSOCIATED LYMPHOID TISSUE' named entity 'IMMUNOMODULATORY' named entity 'TARGETING' named entity 'TREATMENT' named entity 'LIPIDS' named entity 'APPROACH' named entity 'ENHANCED ACTIVITY' named entity 'DISEASES' named entity 'ORAL' named entity 'SIMPLE' named entity 'INCREASE' named entity 'LEAD' named entity 'DECREASED' named entity 'IMMUNE SYSTEM' named entity 'IMMUNOMODULATORS' named entity 'GALT' named entity 'ADDITION' named entity 'WHERE' named entity 'CURRENTLY' named entity 'SERVE' named entity 'UID' named entity 'POLYMER' named entity 'NANOPARTICLE' named entity 'LYMPHATIC SYSTEM' named entity 'IMPAIRED FUNCTION' named entity 'PHYSIOLOGY' named entity 'RANGE' named entity 'HOST' named entity 'IMMUNOMODULATORY' named entity 'CONCENTRATION OF' named entity 'REPRESENT' named entity 'EFFECTS' named entity 'BASED' named entity 'SIDE EFFECTS' named entity 'IMPORTANT' named entity 'PRODRUGS' named entity 'USED' named entity 'TREATED' named entity 'HAEMOSTASIS' named entity 'LYMPHOID TISSUES' named entity 'ADVANCED' named entity 'IMMUNE RESPONSES' named entity 'TARGETING' named entity 'IMMUNE CELLS' named entity 'CHAPTER' covid:arg/3ff014a8bda72130f2d8ba4a7984cca172bc4000 named entity 'host' named entity 'lymphatic system' named entity 'immune system' named entity 'enhance' named entity 'targeting' named entity 'absorption' named entity 'haemostasis' named entity 'This' named entity 'Targeting' named entity 'immunomodulators' named entity 'immunomodulators' named entity 'immune responses' named entity 'immunomodulatory' named entity 'immunomodulators'

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