About: Neutralizing antibody against severe acute respiratory syndrome (SARS)‐coronavirus spike is highly effective for the protection of mice in the murine SARS model

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About: Neutralizing antibody against severe acute respiratory syndrome (SARS)‐coronavirus spike is highly effective for the protection of mice in the murine SARS model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neutralizing antibody against severe acute respiratory syndrome (SARS)‐coronavirus spike is highly effective for the protection of mice in the murine SARS model
Creator	Fukushi, Shuetsu Nagata, Noriyo Taguchi, Fumihiro Ami, Yasushi Hasegawa, Hideki Ishii, Koji Tsunetsugu-Yokota, Yasuko
Source	Medline; PMC
abstract	We evaluated the efficacy of three SARS vaccine candidates in a murine SARS model utilizing low‐virulence Pp and SARS‐CoV coinfection. Vaccinated mice were protected from severe respiratory disease in parallel with a low virus titer in the lungs and a high neutralizing antibody titer in the plasma. Importantly, the administration of spike protein‐specific neutralizing monoclonal antibody protected mice from the disease, indicating that the neutralization is sufficient for protection. Moreover, a high level of IL‐6 and MCP‐1 production, but not other 18 cytokines tested, on days 2 and 3 after SARS‐CoV infection was closely linked to the virus replication and disease severity, suggesting the importance of these cytokines in the lung pathogenicity of SARS‐CoV infection.
has issue date	2008-11-10(xsd:dateTime)
bibo:doi	10.1111/j.1348-0421.2008.00097.x
bibo:pmid	19291090
has license	no-cc
sha1sum (hex)	3fd46c150f6d16309b453514e8536b235dd100d3
schema:url	https://doi.org/10.1111/j.1348-0421.2008.00097.x
resource representing a document's title	Neutralizing antibody against severe acute respiratory syndrome (SARS)‐coronavirus spike is highly effective for the protection of mice in the murine SARS model
has PubMed Central identifier	PMC7168451
has PubMed identifier	19291090
schema:publication	Microbiol Immunol
resource representing a document's body	covid:3fd46c150f6d16309b453514e8536b235dd100d3#body_text
is schema:about of	named entity 'neutralization' named entity 'antibody titer' named entity 'disease' named entity 'neutralizing antibody' named entity 'MCP-1' named entity 'MONOCLONAL ANTIBODY' named entity 'RESPIRATORY DISEASE' named entity 'COINFECTION' named entity 'PROTECTION' named entity 'CYTOKINES' named entity 'SARS VACCINE' named entity 'SARS-COV' named entity 'NEUTRALIZATION' named entity 'SPIKE PROTEIN' named entity 'VIRUS REPLICATION' named entity 'MCP-1 PRODUCTION' named entity 'EVALUATED' named entity 'THESE' named entity 'BUT' named entity 'high level' named entity 'pathogenicity' named entity 'administration' named entity 'evaluated' named entity 'coinfection' named entity 'SARS-CoV' named entity 'replication' named entity 'respiratory disease' named entity 'SARS-CoV' named entity 'severe' named entity 'cytokines' named entity 'cytokines' named entity 'titer' named entity 'murine' named entity 'respiratory disease' named entity 'spike protein' named entity 'SARS' named entity 'infection' named entity 'monoclonal antibody' named entity 'infection' named entity 'SARS' named entity 'plasma' named entity 'DMEM' named entity 'dose-dependent manner' named entity 'density gradient centrifugation' named entity 'IL-6' named entity 'mice' named entity 'mice' named entity 'SARS-CoV' named entity 'microorganisms' named entity 'lungs' named entity 'Austin, TX' named entity 'coinfection' named entity 'alum' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'TNF-α' named entity 'mice' named entity 'vaccine' named entity 'formalin' named entity 'titer' named entity 'SARS' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'MCP-1' named entity 'antibody' named entity 'monokine' named entity 'spike protein' named entity 'lung lavage' named entity 'TNF-α' named entity 'SARS-CoV' named entity 'serologically' named entity 'virus' named entity 'homogenates' named entity 'Vero E6'

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