About: Characterization of the nasopharyngeal viral microbiome from children with community‐acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection

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About: Characterization of the nasopharyngeal viral microbiome from children with community‐acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of the nasopharyngeal viral microbiome from children with community‐acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection
Creator	Liu, Chunyan Ren, Lili Shen, Kunling Xie, Zhengde Zhu, Yun Xu, Lili Xu, \|
Source	Medline; PMC
abstract	In the present study, 50 nasopharyngeal swabs from children with community‐acquired pneumonia (CAP) but negative for 18 common respiratory viruses, as measured by the Luminex xTAG Respiratory Viral Panel Assay, were subjected to multiplex metagenomic analyses using a next‐generation sequencing platform. Taxonomic analysis showed that all sequence reads could be assigned to a specific species. An average of 95.13% were assigned to the Bacteria kingdom, whereas, only 0.72% were potentially virus derived. This snapshot of the respiratory tract virome revealed most viral reads to be respiratory tract related, classified into four known virus families: Paramyxoviridae, Herpesviridae, Anelloviridae, and Polyomaviridae. Importantly, we detected a novel human parainfluenza virus 3 (HPIV 3) strain with a 32‐bp insertion in the haemagglutinin‐neuraminidase (HN) gene that produced a negative result in the Luminex assay, highlighting the strength of virome metagenomic analysis to identify not only novel viruses but also viruses likely to be missed by ordinary clinical tests. Thus, virome metagenomic analysis could become a viable clinical diagnostic method.
has issue date	2017-07-25(xsd:dateTime)
bibo:doi	10.1002/jmv.24895
bibo:pmid	28671295
has license	no-cc
sha1sum (hex)	3fc6971f4f4e0eabb1262fc6b1203e6d6cff9d04
schema:url	https://doi.org/10.1002/jmv.24895
resource representing a document's title	Characterization of the nasopharyngeal viral microbiome from children with community‐acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection
has PubMed Central identifier	PMC7166964
has PubMed identifier	28671295
schema:publication	J Med Virol
resource representing a document's body	covid:3fc6971f4f4e0eabb1262fc6b1203e6d6cff9d04#body_text
is schema:about of	named entity 'respiratory' named entity 'measured' named entity 'community-acquired pneumonia' named entity 'Characterization' named entity 'viruses' named entity 'nasopharyngeal swabs' named entity 'next-generation sequencing' named entity 'neuraminidase' named entity 'viruses' named entity 'PCR' named entity 'metagenomic' named entity 'metagenomic' named entity 'WUPyV' named entity 'viruses' named entity 'next-generation sequencing' named entity 'gene' named entity 'data set' named entity 'Streptococcus pneumoniae' named entity 'microflora' named entity 'viruses' named entity 'SARI' named entity 'deep sequencing' named entity 'immunological' named entity 'Bacteria' named entity 'mucosa' named entity 'host cells' named entity 'pneumonia' named entity 'Rhinovirus C' named entity 'metagenomic analysis' named entity 'respiratory tracts' named entity 'genomes' named entity 'respiratory tracts' named entity 'homologs' named entity 'Adenoviridae' named entity 'pathogens' named entity 'bacteria' named entity 'Anelloviridae' named entity 'taxonomic' named entity 'Anelloviridae' named entity 'microflora' named entity 'control groups' named entity 'glycoprotein' named entity 'pathogens' named entity 'eukaryote' named entity 'SARI' named entity 'Viral metagenomics' named entity 'clinical tests' named entity 'WUPyV' named entity 'respiratory tract' named entity 'metagenomic' named entity 'influenza virus' named entity 'viruses' named entity 'virus' named entity 'clinical tests' named entity 'viruses' named entity 'viruses' named entity 'virus' named entity 'clinical diagnostic' named entity 'HEV' named entity 'Paramyxoviridae' named entity 'cell culture' named entity 'HN gene' named entity 'homology' named entity 'EBV' named entity 'high-throughput' named entity 'virome' named entity 'HRV' named entity 'eukaryotic' named entity 'next-generation sequencing' named entity 'nasopharyngeal' named entity 'microbial' named entity 'human metapneumovirus' named entity 'virome' named entity 'SARI' named entity 'SARI'

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