About: Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19

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About: Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19
Creator	Barzaghini, Bianca Bocconi, Alberto Carelli, Stephana Conci, Claudio Donnaloja, Francesca Jacchetti, Emanuela Parodi, Valentina Raimondi, Manuela
Source	Medline; PMC
abstract	This review provides an update for the international research community on the cell modeling tools that could accelerate the understanding of SARS-CoV-2 infection mechanisms and could thus speed up the development of vaccines and therapeutic agents against COVID-19. Many bioengineering groups are actively developing frontier tools that are capable of providing realistic three-dimensional (3D) models for biological research, including cell culture scaffolds, microfluidic chambers for the culture of tissue equivalents and organoids, and implantable windows for intravital imaging. Here, we review the most innovative study models based on these bioengineering tools in the context of virology and vaccinology. To make it easier for scientists working on SARS-CoV-2 to identify and apply specific tools, we discuss how they could accelerate the discovery and preclinical development of antiviral drugs and vaccines, compared to conventional models.
has issue date	2020-05-27(xsd:dateTime)
bibo:doi	10.7150/thno.47406
bibo:pmid	32641977
has license	cc-by
sha1sum (hex)	3fbd5bd2399feeac0e3c804bd3f807e8ce29c4a8
schema:url	https://doi.org/10.7150/thno.47406
resource representing a document's title	Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19
has PubMed Central identifier	PMC7330866
has PubMed identifier	32641977
schema:publication	Theranostics
resource representing a document's body	covid:3fbd5bd2399feeac0e3c804bd3f807e8ce29c4a8#body_text
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