About: Non‐invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo

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About: Non‐invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Non‐invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo
Creator	Rottier, Peter Raaben, Matthijs De Haan, Cornelis Martens, Anton Prins, Henk-Jan
Source	Medline; PMC
abstract	Bioluminescence imaging (BLI) is a powerful new method to study virus dissemination in the live animal. Here we used this method to monitor the spatial and temporal progression of mouse hepatitis coronavirus (MHV) infection in mice using luciferase‐expressing viruses. Upon intranasal inoculation, virus replication could initially be observed in the nasal cavity and the cervical lymph nodes, after which the infection spread to the brain and frequently to the eyes. The kinetics of virus spread to and clearance from the brain appeared to depend on the inoculation dose. After intraperitoneal inoculation, virus replication was predominantly observed in the liver and occasionally in the intestines, but interestingly also in the tail and paws. BLI thus elucidated new anatomic locations of virus replication. Furthermore, MHV dissemination was shown to be critically depended on the viral spike protein, but also on the mouse strain used. Widespread dissemination was observed in mice lacking a functional type I interferon response. The importance of the type I interferon system in limiting viral spread was also demonstrated by the administration of type I interferons to mice. Our results provide new insights in coronavirus pathogenesis and demonstrate the potential of BLI to study coronavirus–host interactions in vivo.
has issue date	2009-02-10(xsd:dateTime)
bibo:doi	10.1111/j.1462-5822.2009.01298.x
bibo:pmid	19215224
has license	no-cc
sha1sum (hex)	3f966b2ef9c4b413bab7dbe0a11ea753422f8ac4
schema:url	https://doi.org/10.1111/j.1462-5822.2009.01298.x
resource representing a document's title	Non‐invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo
has PubMed Central identifier	PMC7162388
has PubMed identifier	19215224
schema:publication	Cell Microbiol
resource representing a document's body	covid:3f966b2ef9c4b413bab7dbe0a11ea753422f8ac4#body_text
is schema:about of	named entity 'limiting' named entity 'protein' named entity 'replication' named entity 'BLI' named entity 'insights' named entity 'potential' named entity 'virus' named entity 'Here' named entity 'virus' named entity 'mouse' covid:arg/3f966b2ef9c4b413bab7dbe0a11ea753422f8ac4 named entity 'kinetics' named entity 'system' named entity 'mouse' named entity 'cervical lymph nodes' named entity 'critically' named entity 'initially' named entity 'virus replication' named entity 'coronavirus' named entity 'intraperitoneal' named entity 'inoculation' named entity 'virus replication' named entity 'intranasal' named entity 'virus' named entity 'spike protein' named entity 'mice' named entity 'hepatitis' named entity 'inoculation' named entity 'mice' named entity 'anatomic' named entity 'C57BL/6' named entity 'liver' named entity 'MHV' named entity 'inoculation' named entity 'liver' named entity 'virus replication' named entity 'BALB/c' named entity 'pathogen' named entity 'infection' named entity 'infection' named entity 'haemagglutinin' named entity 'BALB/c' named entity 'virulence' named entity 'receptor' named entity 'viral RNA' named entity 'TCID50' named entity 'de Haan' named entity 'wild-type' named entity 'inoculation' named entity 'inoculation' named entity 'recombinants' named entity 'liver' named entity 'liver' named entity 'MHV' named entity 'hepatitis' named entity 'ventral' named entity 'MHV' named entity 'epithelium' named entity 'inoculation' named entity 'pathogenesis' named entity 'virus infections' named entity 'infection throughout the body' named entity 'virus' named entity 'type I IFN' named entity 'tissue culture' named entity 'recombinant' named entity 'virus' named entity 'inoculation' named entity 'photon' named entity 'heparan sulfate' named entity 'type I IFN' named entity 'virus' named entity 'epithelium' named entity 'antiviral agents' named entity 'intraperitoneally' named entity 'inoculation' named entity 'photon'

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