About: Cystatins in Immune System

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cystatins in Immune System
Creator	Kos, Janko Magister, Špela
Source	Medline; PMC
abstract	Cystatins comprise a large superfamily of related proteins with diverse biological activities. They were initially characterised as inhibitors of lysosomal cysteine proteases, however, in recent years some alternative functions for cystatins have been proposed. Cystatins possessing inhibitory function are members of three families, family I (stefins), family II (cystatins) and family III (kininogens). Stefin A is often linked to neoplastic changes in epithelium while another family I cystatin, stefin B is supposed to have a specific role in neuredegenerative diseases. Cystatin C, a typical type II cystatin, is expressed in a variety of human tissues and cells. On the other hand, expression of other type II cystatins is more specific. Cystatin F is an endo/lysosome targeted protease inhibitor, selectively expressed in immune cells, suggesting its role in processes related to immune response. Our recent work points on its role in regulation of dendritic cell maturation and in natural killer cells functional inactivation that may enhance tumor survival. Cystatin E/M expression is mainly restricted to the epithelia of the skin which emphasizes its prominent role in cutaneous biology. Here, we review the current knowledge on type I (stefins A and B) and type II cystatins (cystatins C, F and E/M) in pathologies, with particular emphasis on their suppressive vs. promotional function in the tumorigenesis and metastasis. We proposed that an imbalance between cathepsins and cystatins may attenuate immune cell functions and facilitate tumor cell invasion.
has issue date	2012-12-20(xsd:dateTime)
bibo:doi	10.7150/jca.5044
bibo:pmid	23386904
has license	cc-by-nc-nd
sha1sum (hex)	3f9572ae671d876279b4d2cd6b6544b24fb3e52d
schema:url	https://doi.org/10.7150/jca.5044
resource representing a document's title	Cystatins in Immune System
has PubMed Central identifier	PMC3564246
has PubMed identifier	23386904
schema:publication	J Cancer
resource representing a document's body	covid:3f9572ae671d876279b4d2cd6b6544b24fb3e52d#body_text
is schema:about of	named entity 'IMMUNE SYSTEM' named entity 'CYSTATINS' named entity 'cystatin' named entity 'anti-cancer agents' named entity 'endothelial cell' named entity 'TGF-β' named entity 'cancer cell lines' named entity 'cystatins' named entity 'pathological conditions' named entity 'cystatins' named entity 'effector' named entity 'spermatogenic' named entity 'Alzheimer's disease' named entity 'cysteine' named entity 'protein' named entity 'inflammatory' named entity 'colocalization' named entity 'cystatin' named entity 'liver' named entity 'GFR' named entity 'Trypanosoma cruzi' named entity 'preprotein' named entity 'nucleus' named entity 'cystatin' named entity 'cDNA cloning' named entity 'promoter region' named entity 'cystatins' named entity 'immune response' named entity 'cystatins' named entity 'cystatins' named entity 'monomeric' named entity 'antigen presentation' named entity 'tumor suppressor' named entity 'Cell migration' named entity 'protein degradation' named entity 'cis' named entity 'phosphatases' named entity 'breast tissue' named entity 'neutrophils' named entity 'cystatin' named entity 'Parkinson's disease' named entity 'cysteine proteases' named entity 'prognosis' named entity 'cystatin' named entity 'cysteine proteases' named entity 'TGF-β1' named entity 'proteolytic activity' named entity 'scid' named entity 'cystatin' named entity 'crystal structure' named entity 'proteolytic processing' named entity 'metastatic' named entity 'expression levels' named entity 'antigen presenting cells' named entity 'prognosis' named entity 'transcription factors' named entity 'immunomodulatory' named entity 'colocalization' named entity 'chaperone' named entity 'protein' named entity 'toxicity' named entity 'α-helix' named entity 'bone resorption' named entity 'mRNA expression' named entity 'downstream regulation' named entity 'cathepsin' named entity 'legumain' named entity 'cellular processes' named entity 'intracellular' named entity 'epilepsy' named entity 'immune response' named entity 'type II' named entity 'lysosomal' named entity 'antigen' named entity 'cathepsin' named entity 'downregulated' named entity 'keratinocytes' named entity 'neurodegenerative diseases' named entity 'macrophages' named entity 'papain'

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