About: Animal and translational models of SARS-CoV-2 infection and COVID-19

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About: Animal and translational models of SARS-CoV-2 infection and COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Animal and translational models of SARS-CoV-2 infection and COVID-19
Creator	Liu, G Simpson, S Neely, G Lyons, J Hansbro, P Moreno, C Britton, W Cole, A Couteur, D Donovan, C Faiz, A Gamble, J Gorrell, Hansbro, N Hesselson, D Irving, A Johansen, M Kim, R Mccaughan, G Montagutelli, X Nold, M Nold-Petry, C Oliver, B Rudloff, I Saunders, B Short, K Tate, M Triccas, J Wark, P
Source	Medline; PMC
abstract	COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical community is in a race to define and develop effective preventions and treatments. The major features of disease are described but clinical trials have been hampered by competing interests, small scale, lack of defined patient cohorts and defined readouts. What is needed now is head-to-head comparison of existing drugs, testing of safety including in the background of predisposing chronic diseases, and the development of new and targeted preventions and treatments. This is most efficiently achieved using representative animal models of primary infection including in the background of chronic disease with validation of findings in primary human cells and tissues. We explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1038/s41385-020-00340-z
bibo:pmid	32820248
has license	no-cc
sha1sum (hex)	3f95367e392325cb3e2176ed049c64ccfe225d18
schema:url	https://doi.org/10.1038/s41385-020-00340-z
resource representing a document's title	Animal and translational models of SARS-CoV-2 infection and COVID-19
has PubMed Central identifier	PMC7439637
has PubMed identifier	32820248
schema:publication	Mucosal Immunol
resource representing a document's body	covid:3f95367e392325cb3e2176ed049c64ccfe225d18#body_text
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