About: IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway
Creator	Zhao, Jing Feng, Li Shi, Hongyan Xue, Mei Fu, Fang Liu, Pinghuang Li, Lin Zhang, Jiaoer Ma, Yanlong Ying, Lan
Source	Elsevier; Medline; PMC
abstract	Abstract Interleukin-22 (IL-22), a member of the IL-10 superfamily, plays essential roles in fighting against mucosal microbial infection and maintaining mucosal barrier integrity within the intestine. However, little knowledge exists on the ability of porcine IL-22 (pIL-22) to fight against viral infection in the gut. In this study, we found that recombinant mature pIL-22 (mpIL-22) inhibited the infection of multiple diarrhea viruses, including alpha coronavirus, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine rotavirus (PoRV), in the intestinal porcine epithelial cell line J2 (IPEC-J2) cells. mpIL-22 up-regulated the expression of the antimicrobial peptide beta-defensin (BD-2), cytokine IL-18 and IFN-λ. Furthermore, we found that mpIL-22 induced phosphorylation of STAT3 on Ser727 and Tyr705 in IPEC-J2 cells. Inhibition of STAT3 phosphorylation by S3I-201 abrogated the antiviral ability of mpIL-22 and the mpIL-22-induced expression of BD-2, IL-18, and IFN-λ. Together, mpIL-22 inhibited the infection of PoRV and enteric coronaviruses, and up-regulated the expression of antimicrobial genes in IPEC-J2, which were mediated by the activation of the STAT3 signal pathway. The significant antiviral activity of IL-22 to curtail multiple enteric diarrhea viruses in vitro suggests that pIL-22 could be a novel therapeutic against devastating viral diarrhea in piglets.
has issue date	2017-06-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2017.03.006
bibo:pmid	28322925
has license	els-covid
sha1sum (hex)	3ee3f4f05a87a65b8f18b0a0dfd2c560cdd1166c
schema:url	https://doi.org/10.1016/j.antiviral.2017.03.006
resource representing a document's title	IL-22 suppresses the infection of porcine enteric coronaviruses and rotavirus by activating STAT3 signal pathway
has PubMed Central identifier	PMC7113769
has PubMed identifier	28322925
schema:publication	Antiviral Research
resource representing a document's body	covid:3ee3f4f05a87a65b8f18b0a0dfd2c560cdd1166c#body_text
is schema:about of	named entity 'ACTIVATING' named entity 'INFECTION' named entity 'multiple' named entity 'microbial' named entity 'enteric' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'STAT3' named entity 'BARRIER INTEGRITY' named entity 'DEFENSIN' named entity 'S T' named entity 'IFN' named entity 'INFECTION' named entity 'KNOWLEDGE' named entity 'PIL' named entity 'ESSENTIAL' named entity 'INHIBITION' named entity 'VIRUSES' named entity 'MICROBIAL INFECTION' named entity 'SUPERFAMILY' named entity 'GENES' named entity 'ANTIVIRAL ACTIVITY' named entity 'IN VITRO' named entity 'CELLS' covid:arg/3ee3f4f05a87a65b8f18b0a0dfd2c560cdd1166c named entity 'MUCOSAL' named entity 'ENTERIC' named entity 'ANTIMICROBIAL PEPTIDE' named entity 'VIRAL INFECTION' named entity 'SIGNIFICANT' named entity 'FOUND' named entity 'EXPRESSION' named entity 'PLAYS' named entity 'PORCINE' named entity 'PHOSPHORYLATION' named entity 'IL-18' named entity 'ROLES' named entity 'STAT3' named entity 'ROTAVIRUS' named entity 'PORCINE' named entity 'IL-22' named entity 'SIGNAL PATHWAY' named entity 'SUPPRESSES' named entity 'ABILITY' named entity 'ACTIVATION' named entity 'MEDIATED' named entity 'FIGHTING' named entity 'THERAPEUTIC' named entity 'MULTIPLE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'CORONAVIRUSES' named entity 'ANTIVIRAL' named entity 'ENTERIC' named entity 'INHIBITED' named entity 'CORONAVIRUS' named entity 'INTERLEUKIN-22' named entity 'INDUCED' named entity 'DIARRHEA' named entity 'ALPHA' named entity 'COULD BE' named entity 'THE GUT' named entity 'STUDY' named entity 'BD-2' named entity 'ANTIMICROBIAL' named entity 'S3I-201' named entity 'INTESTINE' named entity 'MEMBER OF' named entity 'SIGNAL PATHWAY' named entity 'RECOMBINANT' named entity 'PORCINE ROTAVIRUS' named entity 'IL-10' named entity 'UP-REGULATED' named entity 'IL-22'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software