About: San‐Huang‐Xie‐Xin‐Tang extract suppresses hepatitis C virus replication and virus‐induced cyclooxygenase‐2 expression

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About: San‐Huang‐Xie‐Xin‐Tang extract suppresses hepatitis C virus replication and virus‐induced cyclooxygenase‐2 expression Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	San‐Huang‐Xie‐Xin‐Tang extract suppresses hepatitis C virus replication and virus‐induced cyclooxygenase‐2 expression
Creator	Chang, F.-R Chiu, C.-C Lee, J.-C Tseng, C.-K Wu, S.-F Wu, Y.-C
Source	Medline; PMC
abstract	Summary. Chronic hepatitis C virus (HCV) infection is associated with chronic inflammation of liver, which leads to the development of cirrhosis and hepatocellular carcinoma (HCC). Because of severe side effects and only a 50–70% cure rate in genotype 1 HCV‐infected patients upon current standard treatment with pegylated interferon‐α plus ribavirin, new therapeutic regimens are still needed. San‐Huang‐Xie‐Xin‐Tang (SHXT) is a transitional Chinese herbal formula, composed of Rhei rhizoma, Scutellaria radix and Coptidis rhizome, and possesses anti‐inflammatory effect. Here, we describe a (+)‐catechin‐containing fraction extracted from SHXT, referred as SHXT‐frC, exhibited effective inhibition of HCV replication, with selectivity index value (SI; CC(50)/EC(50)) of 84, and displayed synergistic anti‐HCV effects when combined with interferon‐α, HCV protease inhibitor telaprevir or polymerase inhibitor 2′‐C‐methylcytidine. The activation of factor‐κB (NF‐κB) and cyclooxygenase‐2 (COX‐2) signalling pathway has particular relevance to HCV‐associated HCC. SHXT‐frC treatment also caused a concentration‐dependent decrease in the induction of COX‐2 and NF‐κB expression caused by either HCV replication or HCV NS5A protein. Collectively, SHXT‐frC could be an adjuvant treatment for patients with HCV‐induced liver diseases.
has issue date	2011-01-20(xsd:dateTime)
bibo:doi	10.1111/j.1365-2893.2010.01424.x
bibo:pmid	21692943
has license	no-cc
sha1sum (hex)	3dd802acc9f1012fabd6433546b8afb5c1524662
schema:url	https://doi.org/10.1111/j.1365-2893.2010.01424.x
resource representing a document's title	San‐Huang‐Xie‐Xin‐Tang extract suppresses hepatitis C virus replication and virus‐induced cyclooxygenase‐2 expression
has PubMed Central identifier	PMC7185454
has PubMed identifier	21692943
schema:publication	J Viral Hepat
resource representing a document's body	covid:3dd802acc9f1012fabd6433546b8afb5c1524662#body_text
is schema:about of	named entity 'activation' named entity 'effects' named entity 'expression' named entity 'pegylated' named entity 'expression' named entity 'POLYMERASE INHIBITOR' named entity 'RHIZOMA' named entity 'REPLICATION' named entity 'SEVERE' named entity 'INHIBITION' named entity 'HEPATOCELLULAR CARCINOMA' named entity 'SYNERGISTIC' named entity 'FORMULA' named entity 'REFERRED' named entity 'CYCLOOXYGENASE-2' named entity 'HEPATITIS C VIRUS' named entity 'COMPOSED OF' named entity 'EFFECTIVE' covid:arg/3dd802acc9f1012fabd6433546b8afb5c1524662 named entity 'Because' named entity 'development' named entity 'cirrhosis' named entity 'patients' named entity 'COX-2' named entity 'replication' named entity 'genotype' named entity 'COX-2' named entity 'HCV' named entity 'signalling pathway' named entity 'cirrhosis' named entity 'telaprevir' named entity 'HCV protease inhibitor' named entity 'COX-2' named entity 'virus' named entity 'HCV' named entity 'catechin' named entity 'catechin' named entity 'P-value' named entity 'COX-2' named entity 'statistical significance' named entity 'antibiotic-antimycotic' named entity 'HCV' named entity 'cirrhosis' named entity 'RNA' named entity 'tumour formation' named entity 'Pharmaceutical' named entity 'HCV' named entity 'VX-950' named entity 'synergistic' named entity 'hepatitis C virus' named entity 'HCV' named entity 'RSV' named entity 'antiviral agents' named entity 'hypotensive' named entity 'RNA' named entity 'P-value' named entity 'St Louis' named entity 'RNA' named entity 'COX-2' named entity 'cyclooxygenase-2' named entity 'Huh-7' named entity 'RT-qPCR' named entity 'gastritis' named entity 'HCV' named entity 'NS5A' named entity 'nonstructural proteins' named entity 'hepatic' named entity 'HCV' named entity 'transfection' named entity 'luciferase' named entity 'COX-2' named entity 'protein' named entity 'plasmid' named entity 'severe acute respiratory syndrome coronavirus' named entity 'carcinogenesis' named entity 'real-time RT-PCR'

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