About: Fetal deaths in pregnancies with SARS-COV-2 infection in Brazil: A case series

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About: Fetal deaths in pregnancies with SARS-COV-2 infection in Brazil: A case series Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fetal deaths in pregnancies with SARS-COV-2 infection in Brazil: A case series
Creator	Silva, Camila Kondo, Kondo, Mario Levi, Jose Richtmann, Rosana Tobara, Mariana Torloni, Maria Almeida, Camila Andrade, Lívio Crema, Mariana Dias, Vilela Galvão, Miglioli Galvão, Pollyanna Lisia, Miglioli Martins Silva, Mario Martins, Pollyanna Otani, Oyamada Phd, Silva Ricardo, Andre Rn, Silva Rn, Tobara
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: There are few reports of miscarriages or stillbirths in women infected with SARS-CoV-2. We present five consecutive cases of fetal death (≥12 weeks) without other putative causes in women with laboratory-confirmed (RT-PCR) COVID-19 managed in a single Brazilian institution. CASE SERIES: All five women were outpatients with mild or moderate forms of COVID-19 and were not taking any medication. Four were nulliparous, all were overweight or obese, and none had any comorbidities or pregnancy complications that could contribute to fetal demise. Fetal death occurred at 21–38 weeks of gestation, on COVID-days 1–22. SARS-Cov-2 was detected by RT-PCR in amniotic fluid in one case and in placental specimens in two cases. All five women had acute chorioamnionitis on placental histology, massive deposition of fibrin, mixed intervillitis/villitis, and intense neutrophil and lymphocyte infiltration. One fetus had neutrophils inside alveolar spaces, suggestive of fetal infection. CONCLUSIONS: These five cases of fetal demise in women with confirmed COVID-19 without any other significant clinical or obstetric disorders suggest that fetal death can be an outcome of SARS-CoV-2 infection in pregnancy. The intense placental inflammatory reaction in all five cases raises the possibility of a direct effect of SARS-CoV-2 on the placenta.
has issue date	2020-07-12(xsd:dateTime)
bibo:doi	10.1016/j.crwh.2020.e00243
bibo:pmid	32704477
has license	no-cc
sha1sum (hex)	3dc7cf4be336b94df75f78b0e41517d323f70fe2
schema:url	https://doi.org/10.1016/j.crwh.2020.e00243
resource representing a document's title	Fetal deaths in pregnancies with SARS-COV-2 infection in Brazil: A case series
has PubMed Central identifier	PMC7354271
has PubMed identifier	32704477
schema:publication	Case Rep Womens Health
resource representing a document's body	covid:3dc7cf4be336b94df75f78b0e41517d323f70fe2#body_text
is schema:about of	named entity 'fetus' named entity 'specimens' named entity 'fetal' named entity 'alveolar' named entity 'fetal death' named entity 'SARS-CoV-2' named entity 'SARS-COV-2' named entity 'MEDICATION' named entity 'FETAL DEMISE' named entity 'OCCURRED' named entity 'SIGNIFICANT' named entity 'LYMPHOCYTE INFILTRATION' named entity 'N A' named entity 'CONSECUTIVE' named entity 'TAKING' named entity 'PREGNANCY COMPLICATIONS' named entity 'CASE SERIES' named entity 'PROOF' named entity 'fetal' named entity 'deposition' named entity 'placental' named entity 'possibility' named entity 'proteinase' named entity 'SARS-CoV-2' named entity 'fetal malformations' named entity 'fetal' named entity 'fetal' named entity 'RT-PCR' named entity 'ischemia' named entity 'autopsies' named entity 'Brazil' named entity 'fetal' named entity 'nasopharyngeal swab' named entity 'afebrile' named entity 'RNA' named entity 'qRT-PCR' named entity 'molecular biology' named entity 'case series' named entity 'COVID' named entity 'RT-PCR' named entity 'COVID' named entity 'placental' named entity 'physical examination' named entity 'afebrile' named entity 'amniotic fluid' named entity 'nasopharyngeal swabs' named entity 'fetal' named entity 'blood pressure' named entity 'pregnancy' named entity 'pregnancy' named entity 'infections during pregnancy' named entity 'physical examination' named entity 'SARS-CoV-2' named entity 'nulliparous' named entity 'FHR' named entity 'SARS-CoV-2' named entity 'pathology laboratory' named entity 'perinatal' named entity 'FHR' named entity 'rhinorrhea' named entity 'obstetric'

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